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    Brown, Nancy

    TitleChemist Senior Sci/Engr
    SchoolLawrence Berkeley National Lab
    DepartmentEnergy Analysis Env Impacts
    Address1 Cyclotron Road
    Berkeley CA 94720
    Phone510/610-7620
    vCardDownload vCard

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Stone C, Brown N. Angiotensin-converting Enzyme Inhibitor and Other Drug-associated Angioedema. Immunol Allergy Clin North Am. 2017 Aug; 37(3):483-495. PMID: 28687104.
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      2. McNaughton CD, Brown N, Rothman RL, Liu D, Kabagambe EK, Levy PD, Self WH, Storrow AB, Collins SP, Roumie CL. Systolic Blood Pressure and Biochemical Assessment of Adherence: A Cross-Sectional Analysis in the Emergency Department. Hypertension. 2017 Jun 26. PMID: 28652467.
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      3. Shuey MM, Billings FT, Wei S, Milne GL, Nian H, Yu C, Brown N. Association of gain-of-function EPHX2 polymorphism Lys55Arg with acute kidney injury following cardiac surgery. PLoS One. 2017; 12(5):e0175292. PMID: 28552948.
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      4. Kodaman N, Sobota RS, Asselbergs FW, Oetjens MT, Moore JH, Brown N, Aldrich MC, Williams SM. Genetic Effects on the Correlation Structure of CVD Risk Factors: Exome-Wide Data From a Ghanaian Population. Glob Heart. 2017 Apr 10. PMID: 28408189.
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      5. Garon SL, Pavlos RK, White KD, Brown N, Stone CA, Phillips EJ. Pharmacogenomics of Off-target ADRs. Br J Clin Pharmacol. 2017 Mar 26. PMID: 28345177.
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      6. Kodaman N, Aldrich MC, Sobota R, Asselbergs FW, Poku KA, Brown N, Moore JH, Williams SM. Cardiovascular Disease Risk Factors in Ghana during the Rural-to-Urban Transition: A Cross-Sectional Study. PLoS One. 2016; 11(10):e0162753. PMID: 27732601.
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      7. Kodaman N, Aldrich MC, Sobota R, Asselbergs FW, Brown N, Moore JH, Williams SM. Plasminogen Activator Inhibitor-1 and Diagnosis of the Metabolic Syndrome in a West African Population. J Am Heart Assoc. 2016 Oct 3; 5(10). PMID: 27697752.
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      8. Wilson JR, Brown N. Examining EXAMINE for an Interaction With Angiotensin-Converting Enzyme Inhibition. Hypertension. 2016 Sep; 68(3):549-51. PMID: 27480841.
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      9. Luther JM, Brown N. Epoxyeicosatrienoic acids and glucose homeostasis in mice and men. Prostaglandins Other Lipid Mediat. 2016 Sep; 125:2-7. PMID: 27448715.
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      10. Billings FT, Brown N. Statins to Reduce Acute Kidney Injury After Cardiac Surgery--Reply. JAMA. 2016 Jul 19; 316(3):349-50. PMID: 27434456.
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      11. Gamboa JL, Billings FT, Bojanowski MT, Gilliam LA, Yu C, Roshanravan B, Roberts LJ, Himmelfarb J, Ikizler TA, Brown N. Mitochondrial dysfunction and oxidative stress in patients with chronic kidney disease. Physiol Rep. 2016 May; 4(9). PMID: 27162261.
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      12. Toh S, Hampp C, Reichman ME, Graham DJ, Balakrishnan S, Pucino F, Hamilton J, Lendle S, Iyer A, Rucker M, Pimentel M, Nathwani N, Griffin MR, Brown N, Fireman BH. Risk for Hospitalized Heart Failure Among New Users of Saxagliptin, Sitagliptin, and Other Antihyperglycemic Drugs: A Retrospective Cohort Study. Ann Intern Med. 2016 Jun 7; 164(11):705-14. PMID: 27110660.
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      13. Sharma A, Bhatt DL, Calvo G, Brown N, Zannad F, Mentz RJ. Heart failure event definitions in drug trials in patients with type 2 diabetes. Lancet Diabetes Endocrinol. 2016 Apr; 4(4):294-6. PMID: 27016320.
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      14. Hubers SA, Brown N. Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition. Circulation. 2016 Mar 15; 133(11):1115-24. PMID: 26976916.
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      15. Billings FT, Hendricks PA, Schildcrout JS, Shi Y, Petracek MR, Byrne JG, Brown N. High-Dose Perioperative Atorvastatin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial. JAMA. 2016 Mar 1; 315(9):877-88. PMID: 26906014.
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      16. Gamboa JL, Devin JK, Ramirez CE, Yu C, Nian H, Lee RH, Brown N. Comparative effects of immediate-release and extended-release aspirin on basal and bradykinin-stimulated excretion of thromboxane and prostacyclin metabolites. Pharmacol Res Perspect. 2016 Apr; 4(2):e00221. PMID: 27069632.
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      17. Ramirez CE, Nian H, Yu C, Gamboa JL, Luther JM, Brown N, Shibao CA. Treatment with Sildenafil Improves Insulin Sensitivity in Prediabetes: A Randomized, Controlled Trial. J Clin Endocrinol Metab. 2015 Dec; 100(12):4533-40. PMID: 26580240.
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      18. Antman EM, Benjamin EJ, Harrington RA, Houser SR, Peterson ED, Bauman MA, Brown N, Bufalino V, Califf RM, Creager MA, Daugherty A, Demets DL, Dennis BP, Ebadollahi S, Jessup M, Lauer MS, Lo B, MacRae CA, McConnell MV, McCray AT, Mello MM, Mueller E, Newburger JW, Okun S, Packer M, Philippakis A, Ping P, Prasoon P, Roger VL, Singer S, Temple R, Turner MB, Vigilante K, Warner J, Wayte P. Acquisition, Analysis, and Sharing of Data in 2015 and Beyond: A Survey of the Landscape: A Conference Report From the American Heart Association Data Summit 2015. J Am Heart Assoc. 2015; 4(11). PMID: 26541391.
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      19. Gamboa JL, Pretorius M, Sprinkel KC, Brown N, Ikizler TA. Angiotensin converting enzyme inhibition increases ADMA concentration in patients on maintenance hemodialysis - a randomized cross-over study. BMC Nephrol. 2015; 16(1):167. PMID: 26494370.
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      20. Majmudar MD, Harrington RA, Brown N, Graham G, McConnell MV. Clinician Innovator: A Novel Career Path in Academic Medicine A Presidentially Commissioned Article From the American Heart Association. J Am Heart Assoc. 2015; 4(10). PMID: 26450117.
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      21. Baudrand R, Goodarzi MO, Vaidya A, Underwood PC, Williams JS, Jeunemaitre X, Hopkins PN, Brown N, Raby BA, Lasky-Su J, Adler GK, Cui J, Guo X, Taylor KD, Chen YD, Xiang A, Raffel LJ, Buchanan TA, Rotter JI, Williams GH, Pojoga LH. A prevalent caveolin-1 gene variant is associated with the metabolic syndrome in Caucasians and Hispanics. Metabolism. 2015 Dec; 64(12):1674-81. PMID: 26475177.
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      22. White MJ, Kodaman NM, Harder RH, Asselbergs FW, Vaughan DE, Brown N, Moore JH, Williams SM. Genetics of Plasminogen Activator Inhibitor-1 (PAI-1) in a Ghanaian Population. PLoS One. 2015; 10(8):e0136379. PMID: 26322636.
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      23. Bastien LA, McDonald BC, Brown N, Harley RA. High-Resolution Mapping of Sources Contributing to Urban Air Pollution Using Adjoint Sensitivity Analysis: Benzene and Diesel Black Carbon. Environ Sci Technol. 2015 Jun 16; 49(12):7276-84. PMID: 26001097.
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      24. Wu JH, Marchioli R, Silletta MG, Masson S, Sellke FW, Libby P, Milne GL, Brown N, Lombardi F, Damiano RJ, Marsala J, Rinaldi M, Domenech A, Simon C, Tavazzi L, Mozaffarian D. Oxidative Stress Biomarkers and Incidence of Postoperative Atrial Fibrillation in the Omega-3 Fatty Acids for Prevention of Postoperative Atrial Fibrillation (OPERA) Trial. J Am Heart Assoc. 2015; 4(5). PMID: 25994442.
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      25. Bowton EA, Collier SP, Wang X, Sutcliffe CB, Van Driest SL, Couch LJ, Herrera M, Jerome RN, Slebos RJ, Alborn WE, Liebler DC, McNaughton CD, Mernaugh RL, Wells QS, Brown N, Roden DM, Pulley JM. Phenotype-Driven Plasma Biobanking Strategies and Methods. J Pers Med. 2015; 5(2):140-52. PMID: 26110578.
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      26. Sidorova TN, Mace LC, Wells KS, Yermalitskaya LV, Su PF, Shyr Y, Atkinson JB, Fogo AB, Prinsen JK, Byrne JG, Petracek MR, Greelish JP, Hoff SJ, Ball SK, Glabe CG, Brown N, Barnett JV, Murray KT. Hypertension is associated with preamyloid oligomers in human atrium: a missing link in atrial pathophysiology? J Am Heart Assoc. 2014; 3(6). PMID: 25468655.
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      27. Benjamin I, Brown N, Burke G, Correa A, Houser SR, Jones DW, Loscalzo J, Vasan RS, Whitman GR. American heart association cardiovascular genome-phenome study: foundational basis and program. Circulation. 2015 Jan 6; 131(1):100-12. PMID: 25411155.
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      28. Ramirez CE, Shuey MM, Milne GL, Gilbert K, Hui N, Yu C, Luther JM, Brown N. Arg287Gln variant of EPHX2 and epoxyeicosatrienoic acids are associated with insulin sensitivity in humans. Prostaglandins Other Lipid Mediat. 2014 Oct; 113-115:38-44. PMID: 25173047.
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      29. Devin JK, Pretorius M, Nian H, Yu C, Billings FT, Brown N. Dipeptidyl-Peptidase 4 Inhibition and the Vascular Effects of Glucagon-like Peptide-1 and Brain Natriuretic Peptide in the Human Forearm. J Am Heart Assoc. 2014; 3(4). PMID: 25158865.
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      30. Luther JM, Byrne LM, Yu C, Wang TJ, Brown N. Dietary sodium restriction decreases insulin secretion without affecting insulin sensitivity in humans. J Clin Endocrinol Metab. 2014 Oct; 99(10):E1895-902. PMID: 25029426.
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      31. Laffer CL, Elijovich F, Eckert GJ, Tu W, Pratt JH, Brown N. Genetic variation in CYP4A11 and blood pressure response to mineralocorticoid receptor antagonism or ENaC inhibition: an exploratory pilot study in African Americans. J Am Soc Hypertens. 2014 Jul; 8(7):475-80. PMID: 25064769.
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      32. Sidorova TN, Mace LC, Wells KS, Yermalitskaya LV, Su PF, Shyr Y, Byrne JG, Petracek MR, Greelish JP, Hoff SJ, Ball SK, Glabe CG, Brown N, Barnett JV, Murray KT. Quantitative Imaging of Preamyloid Oligomers, a Novel Structural Abnormality, in Human Atrial Samples. J Histochem Cytochem. 2014 Jul; 62(7):479-87. PMID: 24789805.
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      33. Marney AM, Brown N, Tamboli R, Abumrad N. Changes in B-Type Natriuretic Peptide and BMI Following Roux-en-Y Gastric Bypass Surgery. Diabetes Care. 2014 Apr; 37(4):e70-1. PMID: 24652734.
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      34. Devin JK, Pretorius M, Nian H, Yu C, Billings FT, Brown N. Substance p increases sympathetic activity during combined Angiotensin-converting enzyme and dipeptidyl peptidase-4 inhibition. Hypertension. 2014 May; 63(5):951-7. PMID: 24516103.
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      35. Wu JH, Marchioli R, Silletta MG, Macchia A, Song X, Siscovick DS, Harris WS, Masson S, Latini R, Albert C, Brown N, Lamarra M, Favaloro RR, Mozaffarian D. Plasma phospholipid omega-3 fatty acids and incidence of postoperative atrial fibrillation in the OPERA trial. J Am Heart Assoc. 2013 Oct; 2(5):e000397. PMID: 24145742.
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      36. Pare G, Kubo M, Byrd JB, McCarty CA, Woodard-Grice A, Teo KK, Anand SS, Zuvich RL, Bradford Y, Ross S, Nakamura Y, Ritchie M, Brown N. Genetic variants associated with angiotensin-converting enzyme inhibitor-associated angioedema. Pharmacogenet Genomics. 2013 Sep; 23(9):470-8. PMID: 23838604.
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      37. Dias E, Hachey B, McNaughton C, Nian H, Yu C, Straka B, Brown N, Caprioli RM. An LC-MS assay for the screening of cardiovascular medications in human samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Oct 15; 937:44-53. PMID: 24013190.
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      38. Brown N, Falck JR. Introduction. P450 metabolites of arachidonic acid--from biochemistry to therapy. Prostaglandins Other Lipid Mediat. 2013 Jul-Aug; 104-105:1. PMID: 23809194.
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      39. Straka B, Nian H, Sloan C, Byrd JB, Woodard-Grice A, Yu C, Stone E, Steven G, Hartert T, Teo KK, Pare G, McCarty CA, Brown N. Pollen count and presentation of Angiotensin-converting enzyme inhibitor-associated angioedema. J Allergy Clin Immunol Pract. 2013 Sep-Oct; 1(5):468-473.e4. PMID: 24565618.
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      40. Brown N. Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis. Nat Rev Nephrol. 2013 Aug; 9(8):459-69. PMID: 23774812.
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      41. Gilbert K, Nian H, Yu C, Luther JM, Brown N. Fenofibrate lowers blood pressure in salt-sensitive but not salt-resistant hypertension. J Hypertens. 2013 Apr; 31(4):820-9. PMID: 23385647.
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      42. Theobald CN, Stover DG, Choma NN, Hathaway J, Green JK, Peterson NB, Sponsler KC, Vasilevskis EE, Kripalani S, Sergent J, Brown N, Denny JC. The effect of reducing maximum shift lengths to 16 hours on internal medicine interns' educational opportunities. Acad Med. 2013 Apr; 88(4):512-8. PMID: 23425987.
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      43. Brown N. Developing physician-scientists: a perspective. Trans Am Clin Climatol Assoc. 2013; 124:218-29. PMID: 23874028.
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      44. Pretorius M, Murray KT, Yu C, Byrne JG, Billings FT, Petracek MR, Greelish JP, Hoff SJ, Ball SK, Mishra V, Body SC, Brown N. Angiotensin-converting enzyme inhibition or mineralocorticoid receptor blockade do not affect prevalence of atrial fibrillation in patients undergoing cardiac surgery. Crit Care Med. 2012 Oct; 40(10):2805-12. PMID: 22824930.
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      45. Marczak ED, Marzec J, Zeldin DC, Kleeberger SR, Brown N, Pretorius M, Lee CR. Polymorphisms in the transcription factor NRF2 and forearm vasodilator responses in humans. Pharmacogenet Genomics. 2012 Aug; 22(8):620-8. PMID: 22668754.
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      46. Kelly DM, Bennett R, Brown N, McCoy J, Boerner D, Yu C, Eghtesad B, Barsoum W, Fung JJ, Kattan MW. Predicting the discharge status after liver transplantation at a single center: a new approach for a new era. Liver Transpl. 2012 Jul; 18(7):796-802. PMID: 22454258.
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      47. Billings FT, Pretorius M, Schildcrout JS, Mercaldo ND, Byrne JG, Ikizler TA, Brown N. Obesity and oxidative stress predict AKI after cardiac surgery. J Am Soc Nephrol. 2012 Jul; 23(7):1221-8. PMID: 22626819.
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      48. Luther JM, Luo P, Wang Z, Cohen SE, Kim HS, Fogo AB, Brown N. Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury. Kidney Int. 2012 Sep; 82(6):643-51. PMID: 22622494.
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      49. Williams JS, Chamarthi B, Goodarzi MO, Pojoga LH, Sun B, Garza AE, Raby BA, Adler GK, Hopkins PN, Brown N, Jeunemaitre X, Ferri C, Fang R, Leonor T, Cui J, Guo X, Taylor KD, Ida Chen YD, Xiang A, Raffel LJ, Buchanan TA, Rotter JI, Williams GH, Shi Y. Lysine-specific demethylase 1: an epigenetic regulator of salt-sensitive hypertension. Am J Hypertens. 2012 Jul; 25(7):812-7. PMID: 22534796.
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      50. Brown N. Cardiovascular effects of antidiabetic agents: focus on blood pressure effects of incretin-based therapies. J Am Soc Hypertens. 2012 May-Jun; 6(3):163-8. PMID: 22433315.
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      51. Delaney JT, Jeff JM, Brown N, Pretorius M, Okafor HE, Darbar D, Roden DM, Crawford DC. Characterization of genome-wide association-identified variants for atrial fibrillation in African Americans. PLoS One. 2012; 7(2):e32338. PMID: 22384221.
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      52. Ayers K, Byrne LM, DeMatteo A, Brown N. Differential effects of nebivolol and metoprolol on insulin sensitivity and plasminogen activator inhibitor in the metabolic syndrome. Hypertension. 2012 Apr; 59(4):893-8. PMID: 22353614.
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      53. Gamboa JL, Pretorius M, Todd-Tzanetos DR, Luther JM, Yu C, Ikizler TA, Brown N. Comparative effects of angiotensin-converting enzyme inhibition and angiotensin-receptor blockade on inflammation during hemodialysis. J Am Soc Nephrol. 2012 Feb; 23(2):334-42. PMID: 22158433.
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      54. McDonald-Buller EC, Allen DT, Brown N, Jacob DJ, Jaffe D, Kolb CE, Lefohn AS, Oltmans S, Parrish DD, Yarwood G, Zhang L. Establishing policy relevant background (PRB) ozone concentrations in the United States. Environ Sci Technol. 2011 Nov 15; 45(22):9484-97. PMID: 21985705.
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      55. Todd Tzanetos DR, Yu C, Hernanz-Schulman M, Barr FE, Brown N. Prospective study of the incidence and predictors of thrombus in children undergoing palliative surgery for single ventricle physiology. Intensive Care Med. 2012 Jan; 38(1):105-12. PMID: 21979273.
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      56. Williams JS, Hopkins PN, Jeunemaitre X, Brown N. CYP4A11 T8590C polymorphism, salt-sensitive hypertension, and renal blood flow. J Hypertens. 2011 Oct; 29(10):1913-8. PMID: 21873888.
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      57. Luther JM, Brown N. The renin-angiotensin-aldosterone system and glucose homeostasis. Trends Pharmacol Sci. 2011 Dec; 32(12):734-9. PMID: 21880378.
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      58. Darbar M, Emans SJ, Harris ZL, Brown N, Scott TA, Cooper WO. Part-time physician faculty in a pediatrics department: a study of equity in compensation and academic advancement. Acad Med. 2011 Aug; 86(8):968-73. PMID: 21694562.
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      59. Chan KE, Ikizler TA, Gamboa JL, Yu C, Hakim RM, Brown N. Combined angiotensin-converting enzyme inhibition and receptor blockade associate with increased risk of cardiovascular death in hemodialysis patients. Kidney Int. 2011 Nov; 80(9):978-85. PMID: 21775975.
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      60. Vaidya A, Sun B, Forman JP, Hopkins PN, Brown N, Kolatkar NS, Williams GH, Williams JS. The Fok1 vitamin D receptor gene polymorphism is associated with plasma renin activity in Caucasians. Clin Endocrinol (Oxf). 2011 Jun; 74(6):783-90. PMID: 21521263.
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      61. Sun B, Williams JS, Pojoga L, Chamarthi B, Lasky-Su J, Raby BA, Hopkins PN, Jeunemaitre X, Brown N, Ferri C, Williams GH. Renin gene polymorphism: its relationship to hypertension, renin levels and vascular responses. J Renin Angiotensin Aldosterone Syst. 2011 Dec; 12(4):564-71. PMID: 21490026.
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      62. Penrod NM, Poku KA, Vaughan DE, Vaughn DE, Asselbergs FW, Brown N, Moore JH, Williams SM. Epistatic interactions in genetic regulation of t-PA and PAI-1 levels in a Ghanaian population. PLoS One. 2011; 6(1):e16639. PMID: 21304999.
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      63. Brown N. This is not Dr. Conn's aldosterone anymore. Trans Am Clin Climatol Assoc. 2011; 122:229-43. PMID: 21686229.
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      64. Billings FT, Pretorius M, Siew ED, Yu C, Brown N. Early postoperative statin therapy is associated with a lower incidence of acute kidney injury after cardiac surgery. J Cardiothorac Vasc Anesth. 2010 Dec; 24(6):913-20. PMID: 20599398.
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      65. Lee CR, Pretorius M, Schuck RN, Burch LH, Bartlett J, Williams SM, Zeldin DC, Brown N. Genetic variation in soluble epoxide hydrolase (EPHX2) is associated with forearm vasodilator responses in humans. Hypertension. 2011 Jan; 57(1):116-22. PMID: 21098312.
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      66. Garg R, Williams GH, Hurwitz S, Brown N, Hopkins PN, Adler GK. Low-salt diet increases insulin resistance in healthy subjects. Metabolism. 2011 Jul; 60(7):965-8. PMID: 21036373.
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      67. Woodard-Grice AV, Lucisano AC, Byrd JB, Stone ER, Simmons WH, Brown N. Sex-dependent and race-dependent association of XPNPEP2 C-2399A polymorphism with angiotensin-converting enzyme inhibitor-associated angioedema. Pharmacogenet Genomics. 2010 Sep; 20(9):532-6. PMID: 20625347.
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      68. Marney A, Kunchakarra S, Byrne L, Brown N. Interactive hemodynamic effects of dipeptidyl peptidase-IV inhibition and angiotensin-converting enzyme inhibition in humans. Hypertension. 2010 Oct; 56(4):728-33. PMID: 20679179.
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      69. Brown N. Therapeutic potential of plasminogen activator inhibitor-1 inhibitors. Ther Adv Cardiovasc Dis. 2010 Oct; 4(5):315-24. PMID: 20660535.
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      70. Underwood PC, Sun B, Williams JS, Pojoga LH, Chamarthi B, Lasky-Su J, Raby BA, Hopkins PN, Jeunemaitre X, Brown N, Adler GK, Williams GH. The relationship between peroxisome proliferator-activated receptor-gamma and renin: a human genetics study. J Clin Endocrinol Metab. 2010 Sep; 95(9):E75-9. PMID: 20631015.
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      71. Gilbert KC, Brown N. Aldosterone and inflammation. Curr Opin Endocrinol Diabetes Obes. 2010 Jun; 17(3):199-204. PMID: 20422780.
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      72. Adam A, Montpas N, Keire D, Désormeaux A, Brown N, Marceau F, Westenberger B. Bradykinin forming capacity of oversulfated chondroitin sulfate contaminated heparin in vitro. Biomaterials. 2010 Aug; 31(22):5741-8. PMID: 20427081.
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      73. Fong P, Stafforini DM, Brown N, Pretorius M. Increased blood flow induces oxidative stress through an endothelium- and nitric oxide-independent mechanism. Free Radic Biol Med. 2010 Jul 15; 49(2):301-5. PMID: 20423727.
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      74. Saxena AR, Karumanchi SA, Brown N, Royle CM, McElrath TF, Seely EW. Increased sensitivity to angiotensin II is present postpartum in women with a history of hypertensive pregnancy. Hypertension. 2010 May; 55(5):1239-45. PMID: 20308605.
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      75. Brown N, Pretorius M. Letter by Brown and Pretorius regarding article, "effect of sulfaphenazole on tissue plasminogen activator release in normotensive subjects and hypertensive patients". Circulation. 2009 Nov 10; 120(19):e159; author reply e160. PMID: 19901200.
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      76. Pretorius M, Brown N. Endogenous nitric oxide contributes to bradykinin-stimulated glucose uptake but attenuates vascular tissue-type plasminogen activator release. J Pharmacol Exp Ther. 2010 Jan; 332(1):291-7. PMID: 19841473.
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      77. Body SC, Collard CD, Shernan SK, Fox AA, Liu KY, Ritchie MD, Perry TE, Muehlschlegel JD, Aranki S, Donahue BS, Pretorius M, Estrada JC, Ellinor PT, Newton-Cheh C, Seidman CE, Seidman JG, Herman DS, Lichtner P, Meitinger T, Pfeufer A, Kääb S, Brown N, Roden DM, Darbar D. Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery. Circ Cardiovasc Genet. 2009 Oct; 2(5):499-506. PMID: 20031626.
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      78. Marney AM, Ma J, Luther JM, Ikizler TA, Brown N. Endogenous bradykinin contributes to increased plasminogen activator inhibitor 1 antigen following hemodialysis. J Am Soc Nephrol. 2009 Oct; 20(10):2246-52. PMID: 19628666.
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      79. Brown N, Byiers S, Carr D, Maldonado M, Warner BA. Dipeptidyl peptidase-IV inhibitor use associated with increased risk of ACE inhibitor-associated angioedema. Hypertension. 2009 Sep; 54(3):516-23. PMID: 19581505.
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      80. Lea WB, Kwak ES, Luther JM, Fowler SM, Wang Z, Ma J, Fogo AB, Brown N. Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt. Kidney Int. 2009 May; 75(9):936-44. PMID: 19225557.
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      81. Hill KD, Eckhauser AW, Marney A, Brown N. Phosphodiesterase 5 inhibition improves beta-cell function in metabolic syndrome. Diabetes Care. 2009 May; 32(5):857-9. PMID: 19196886.
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      82. Brown N. Salt in the wound. J Am Soc Nephrol. 2009 Jan; 20(1):5-6. PMID: 19118146.
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      83. Luther JM, Wang Z, Ma J, Makhanova N, Kim HS, Brown N. Endogenous aldosterone contributes to acute angiotensin II-stimulated plasminogen activator inhibitor-1 and preproendothelin-1 expression in heart but not aorta. Endocrinology. 2009 May; 150(5):2229-36. PMID: 19106220.
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      84. Edgerton DS, Cherrington AD, Neal DW, Scott M, Lautz M, Brown N, Petro J, Hobbs CH, Leach C, Del Parigi A, Strack TR. Inhaled insulin is associated with prolonged enhancement of glucose disposal in muscle and liver in the canine. J Pharmacol Exp Ther. 2009 Mar; 328(3):970-5. PMID: 19098161.
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      85. Kim KM, Henderson GN, Frye RF, Galloway CD, Brown N, Segal MS, Imaram W, Angerhofer A, Johnson RJ. Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jan 1; 877(1-2):65-70. PMID: 19081307.
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      86. Brown AM, Morrow JD, Limbird LE, Byrne DW, Gabbe SG, Balser JR, Brown N. Centralized oversight of physician-scientist faculty development at Vanderbilt: early outcomes. Acad Med. 2008 Oct; 83(10):969-75. PMID: 18820531.
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      87. Fleming GA, Murray KT, Yu C, Byrne JG, Greelish JP, Petracek MR, Hoff SJ, Ball SK, Brown N, Pretorius M. Milrinone use is associated with postoperative atrial fibrillation after cardiac surgery. Circulation. 2008 Oct 14; 118(16):1619-25. PMID: 18824641.
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      88. Walsh RM, Vogt DP, Henderson JM, Hirose K, Mason T, Bencsath K, Hammel J, Brown N. Management of suspected pancreatic cystic neoplasms based on cyst size. Surgery. 2008 Oct; 144(4):677-84; discussion 684-5. PMID: 18847654.
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      89. Jin L, Tonse S, Cohan DS, Mao X, Harley RA, Brown N. Sensitivity analysis of ozone formation and transport for a central California air pollution episode. Environ Sci Technol. 2008 May 15; 42(10):3683-9. PMID: 18546708.
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      90. Gainer JV, Lipkowitz MS, Yu C, Waterman MR, Dawson EP, Capdevila JH, Brown N. Association of a CYP4A11 variant and blood pressure in black men. J Am Soc Nephrol. 2008 Aug; 19(8):1606-12. PMID: 18385420.
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      91. Pretorius M, van Guilder GP, Guzman RJ, Luther JM, Brown N. 17Beta-estradiol increases basal but not bradykinin-stimulated release of active t-PA in young postmenopausal women. Hypertension. 2008 Apr; 51(4):1190-6. PMID: 18259028.
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      92. Laffer CL, Gainer JV, Waterman MR, Capdevila JH, Laniado-Schwartzman M, Nasjletti A, Brown N, Elijovich F. The T8590C polymorphism of CYP4A11 and 20-hydroxyeicosatetraenoic acid in essential hypertension. Hypertension. 2008 Mar; 51(3):767-72. PMID: 18227405.
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      93. Van Guilder GP, Pretorius M, Luther JM, Byrd JB, Hill K, Gainer JV, Brown N. Bradykinin type 2 receptor BE1 genotype influences bradykinin-dependent vasodilation during angiotensin-converting enzyme inhibition. Hypertension. 2008 Feb; 51(2):454-9. PMID: 18180402.
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      94. Brown N. Aldosterone and vascular inflammation. Hypertension. 2008 Feb; 51(2):161-7. PMID: 18172061.
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      95. Byrd JB, Touzin K, Sile S, Gainer JV, Yu C, Nadeau J, Adam A, Brown N. Dipeptidyl peptidase IV in angiotensin-converting enzyme inhibitor associated angioedema. Hypertension. 2008 Jan; 51(1):141-7. PMID: 18025295.
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      96. Sile S, Gillani NB, Velez DR, Vanoye CG, Yu C, Byrne LM, Gainer JV, Brown N, Williams SM, George AL. Functional BSND variants in essential hypertension. Am J Hypertens. 2007 Nov; 20(11):1176-1182. PMID: 17954364.
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      97. Walsh RM, Henderson JM, Vogt DP, Brown N. Long-term outcome of biliary reconstruction for bile duct injuries from laparoscopic cholecystectomies. Surgery. 2007 Oct; 142(4):450-6; discussion 456-7. PMID: 17950335.
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      98. Pretorius M, Donahue BS, Yu C, Greelish JP, Roden DM, Brown N. Plasminogen activator inhibitor-1 as a predictor of postoperative atrial fibrillation after cardiopulmonary bypass. Circulation. 2007 Sep 11; 116(11 Suppl):I1-7. PMID: 17846288.
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      99. Marney AM, Brown N. Aldosterone and end-organ damage. Clin Sci (Lond). 2007 Sep; 113(6):267-78. PMID: 17683282.
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      100. Byrd JB, Shreevatsa A, Putlur P, Foretia D, McAlexander L, Sinha T, Does MD, Brown N. Dipeptidyl peptidase IV deficiency increases susceptibility to angiotensin-converting enzyme inhibitor-induced peritracheal edema. J Allergy Clin Immunol. 2007 Aug; 120(2):403-8. PMID: 17531305.
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      101. Muldowney JA, Painter CA, Sanders-Bush E, Brown N, Vaughan DE. Acute tissue-type plasminogen activator release in human microvascular endothelial cells: the roles of Galphaq, PLC-beta, IP3 and 5,6-epoxyeicosatrienoic acid. Thromb Haemost. 2007 Feb; 97(2):263-71. PMID: 17264956.
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      102. Chamarthi B, Kolatkar NS, Hunt SC, Williams JS, Seely EW, Brown N, Murphey LJ, Jeunemaitre X, Williams GH. Urinary free cortisol: an intermediate phenotype and a potential genetic marker for a salt-resistant subset of essential hypertension. J Clin Endocrinol Metab. 2007 Apr; 92(4):1340-6. PMID: 17264181.
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      103. Gumieniak O, Perlstein TS, Williams JS, Hopkins PN, Brown N, Raby BA, Williams GH. Ala92 type 2 deiodinase allele increases risk for the development of hypertension. Hypertension. 2007 Mar; 49(3):461-6. PMID: 17224473.
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      104. Williams SM, Stocki S, Jiang L, Brew K, Gordon S, Vaughan DE, Brown N, Poku KA, Moore JH. A population-based study in Ghana to investigate inter-individual variation in plasma t-PA and PAI-1. Ethn Dis. 2007; 17(3):492-7. PMID: 17985503.
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      105. LeFebvre J, Shintani A, Gebretsadik T, Petro JR, Murphey LJ, Brown N. Bradykinin B(2) receptor does not contribute to blood pressure lowering during AT(1) receptor blockade. J Pharmacol Exp Ther. 2007 Mar; 320(3):1261-7. PMID: 17182977.
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      106. Byrd JB, Adam A, Brown N. Angiotensin-converting enzyme inhibitor-associated angioedema. Immunol Allergy Clin North Am. 2006 Nov; 26(4):725-37. PMID: 17085287.
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      107. Luther JM, Gainer JV, Murphey LJ, Yu C, Vaughan DE, Morrow JD, Brown N. Angiotensin II induces interleukin-6 in humans through a mineralocorticoid receptor-dependent mechanism. Hypertension. 2006 Dec; 48(6):1050-7. PMID: 17043157.
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      108. Pojoga L, Kolatkar NS, Williams JS, Perlstein TS, Jeunemaitre X, Brown N, Hopkins PN, Raby BA, Williams GH. Beta-2 adrenergic receptor diplotype defines a subset of salt-sensitive hypertension. Hypertension. 2006 Nov; 48(5):892-900. PMID: 17015767.
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      109. Murphey LJ, Malave HA, Petro J, Biaggioni I, Byrne DW, Vaughan DE, Luther JM, Pretorius M, Brown N. Bradykinin and its metabolite bradykinin 1-5 inhibit thrombin-induced platelet aggregation in humans. J Pharmacol Exp Ther. 2006 Sep; 318(3):1287-92. PMID: 16772538.
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      110. Brown N. Blood pressure reduction and tissue-type plasminogen activator release. Hypertension. 2006 Apr; 47(4):648-9. PMID: 16520404.
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      111. Brown N, Muldowney JA, Vaughan DE. Endogenous NO regulates plasminogen activator inhibitor-1 during angiotensin-converting enzyme inhibition. Hypertension. 2006 Mar; 47(3):441-8. PMID: 16432054.
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      112. Motsinger AA, Donahue BS, Brown N, Roden DM, Ritchie MD. Risk factor interactions and genetic effects associated with post-operative atrial fibrillation. Pac Symp Biocomput. 2006; 584-95. PMID: 17094271.
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      113. Pretorius M, Scholl FG, McFarlane JA, Murphey LJ, Brown N. A pilot study indicating that bradykinin B2 receptor antagonism attenuates protamine-related hypotension after cardiopulmonary bypass. Clin Pharmacol Ther. 2005 Nov; 78(5):477-85. PMID: 16321614.
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      114. Aldigier JC, Kanjanbuch T, Ma LJ, Brown N, Fogo AB. Regression of existing glomerulosclerosis by inhibition of aldosterone. J Am Soc Nephrol. 2005 Nov; 16(11):3306-14. PMID: 16192423.
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      115. Pretorius M, Luther JM, Murphey LJ, Vaughan DE, Brown N. Angiotensin-converting enzyme inhibition increases basal vascular tissue plasminogen activator release in women but not in men. Arterioscler Thromb Vasc Biol. 2005 Nov; 25(11):2435-40. PMID: 16166566.
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      116. Duan QL, Nikpoor B, Dube MP, Molinaro G, Meijer IA, Dion P, Rochefort D, Saint-Onge J, Flury L, Brown N, Gainer JV, Rouleau JL, Agostoni A, Cugno M, Simon P, Clavel P, Potier J, Wehbe B, Benarbia S, Marc-Aurele J, Chanard J, Foroud T, Adam A, Rouleau GA. A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors. Am J Hum Genet. 2005 Oct; 77(4):617-26. PMID: 16175507.
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      117. Moreau ME, Garbacki N, Molinaro G, Brown N, Marceau F, Adam A. The kallikrein-kinin system: current and future pharmacological targets. J Pharmacol Sci. 2005 Sep; 99(1):6-38. PMID: 16177542.
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      118. Xu BJ, Shyr Y, Liang X, Ma LJ, Donnert EM, Roberts JD, Zhang X, Kon V, Brown N, Caprioli RM, Fogo AB. Proteomic patterns and prediction of glomerulosclerosis and its mechanisms. J Am Soc Nephrol. 2005 Oct; 16(10):2967-75. PMID: 16079267.
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      119. Ma J, Albornoz F, Yu C, Byrne DW, Vaughan DE, Brown N. Differing effects of mineralocorticoid receptor-dependent and -independent potassium-sparing diuretics on fibrinolytic balance. Hypertension. 2005 Aug; 46(2):313-20. PMID: 15998706.
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      120. Brown N. Aldosterone and end-organ damage. Curr Opin Nephrol Hypertens. 2005 May; 14(3):235-41. PMID: 15821416.
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      121. King LM, Gainer JV, David GL, Dai D, Goldstein JA, Brown N, Zeldin DC. Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension. Pharmacogenet Genomics. 2005 Jan; 15(1):7-13. PMID: 15864120.
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      122. Gainer JV, Bellamine A, Dawson EP, Womble KE, Grant SW, Wang Y, Cupples LA, Guo CY, Demissie S, O'Donnell CJ, Brown N, Waterman MR, Capdevila JH. Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. Circulation. 2005 Jan 4; 111(1):63-9. PMID: 15611369.
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      123. Weisberg AD, Albornoz F, Griffin JP, Crandall DL, Elokdah H, Fogo AB, Vaughan DE, Brown N. Pharmacological inhibition and genetic deficiency of plasminogen activator inhibitor-1 attenuates angiotensin II/salt-induced aortic remodeling. Arterioscler Thromb Vasc Biol. 2005 Feb; 25(2):365-71. PMID: 15576638.
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      124. Perlstein TS, Gumieniak O, Hopkins PN, Murphey LJ, Brown N, Williams GH, Hollenberg NK, Fisher ND. Uric acid and the state of the intrarenal renin-angiotensin system in humans. Kidney Int. 2004 Oct; 66(4):1465-70. PMID: 15458439.
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      125. Pretorius M, McFarlane JA, Vaughan DE, Brown N, Murphey LJ. Angiotensin-converting enzyme inhibition and smoking potentiate the kinin response to cardiopulmonary bypass. Clin Pharmacol Ther. 2004 Oct; 76(4):379-87. PMID: 15470338.
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      126. Muldowney JA, Davis SN, Vaughan DE, Brown N. NO synthase inhibition increases aldosterone in humans. Hypertension. 2004 Nov; 44(5):739-45. PMID: 15381675.
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      127. Gumieniak O, Perlstein TS, Hopkins PN, Brown N, Murphey LJ, Jeunemaitre X, Hollenberg NK, Williams GH. Thyroid function and blood pressure homeostasis in euthyroid subjects. J Clin Endocrinol Metab. 2004 Jul; 89(7):3455-61. PMID: 15240631.
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      128. Ridker PM, Brown N, Vaughan DE, Harrison DG, Mehta JL. Established and emerging plasma biomarkers in the prediction of first atherothrombotic events. Circulation. 2004 Jun 29; 109(25 Suppl 1):IV6-19. PMID: 15226246.
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      129. Nieman MT, Warnock M, Hasan AA, Mahdi F, Lucchesi BR, Brown N, Murphey LJ, Schmaier AH. The preparation and characterization of novel peptide antagonists to thrombin and factor VIIa and activation of protease-activated receptor 1. J Pharmacol Exp Ther. 2004 Nov; 311(2):492-501. PMID: 15210836.
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      130. Coffey CS, Hebert PR, Ritchie MD, Krumholz HM, Gaziano JM, Ridker PM, Brown N, Vaughan DE, Moore JH. An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction: the importance of model validation. BMC Bioinformatics. 2004 Apr 30; 5:49. PMID: 15119966.
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      131. Summar ML, Hall L, Christman B, Barr F, Smith H, Kallianpur A, Brown N, Yadav M, Willis A, Eeds A, Cermak E, Summar S, Wilson A, Arvin M, Putnam A, Wills M, Cunningham G. Environmentally determined genetic expression: clinical correlates with molecular variants of carbamyl phosphate synthetase I. Mol Genet Metab. 2004 Apr; 81 Suppl 1:S12-9. PMID: 15050969.
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      132. Ma LJ, Mao SL, Taylor KL, Kanjanabuch T, Guan Y, Zhang Y, Brown N, Swift LL, McGuinness OP, Wasserman DH, Vaughan DE, Fogo AB. Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1. Diabetes. 2004 Feb; 53(2):336-46. PMID: 14747283.
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      133. Summar ML, Gainer JV, Pretorius M, Malave H, Harris S, Hall LD, Weisberg A, Vaughan DE, Christman BW, Brown N. Relationship between carbamoyl-phosphate synthetase genotype and systemic vascular function. Hypertension. 2004 Feb; 43(2):186-91. PMID: 14718356.
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      134. Murphey LJ, Eccles WK, Williams GH, Brown N. Loss of sodium modulation of plasma kinins in human hypertension. J Pharmacol Exp Ther. 2004 Mar; 308(3):1046-52. PMID: 14718610.
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      135. Pretorius M, Murphey LJ, McFarlane JA, Vaughan DE, Brown N. Angiotensin-converting enzyme inhibition alters the fibrinolytic response to cardiopulmonary bypass. Circulation. 2003 Dec 23; 108(25):3079-83. PMID: 14656921.
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      136. Lunden MM, Thatcher TL, Hering SV, Brown N. Use of time- and chemically resolved particulate data to characterize the infiltration of outdoor PM2.5 into a residence in the San Joaquin Valley. Environ Sci Technol. 2003 Oct 15; 37(20):4724-32. PMID: 14594384.
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      137. Murphey LJ, Morrow JD, Sawathiparnich P, Williams GH, Vaughan DE, Brown N. Acute angiotensin II increases plasma F2-isoprostanes in salt-replete human hypertensives. Free Radic Biol Med. 2003 Oct 1; 35(7):711-8. PMID: 14583335.
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      138. Sawathiparnich P, Murphey LJ, Kumar S, Vaughan DE, Brown N. Effect of combined AT1 receptor and aldosterone receptor antagonism on plasminogen activator inhibitor-1. J Clin Endocrinol Metab. 2003 Aug; 88(8):3867-73. PMID: 12915681.
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      139. Brown N. Eplerenone: cardiovascular protection. Circulation. 2003 May 20; 107(19):2512-8. PMID: 12756192.
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      140. Fischer ML, Littlejohn D, Lunden MM, Brown N. Automated measurements of ammonia and nitric acid in indoor and outdoor air. Environ Sci Technol. 2003 May 15; 37(10):2114-9. PMID: 12785515.
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      141. Pretorius M, Rosenbaum D, Vaughan DE, Brown N. Angiotensin-converting enzyme inhibition increases human vascular tissue-type plasminogen activator release through endogenous bradykinin. Circulation. 2003 Feb 4; 107(4):579-85. PMID: 12566370.
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      142. Bellamine A, Wang Y, Waterman MR, Gainer JV, Dawson EP, Brown N, Capdevila JH. Characterization of the CYP4A11 gene, a second CYP4A gene in humans. Arch Biochem Biophys. 2003 Jan 1; 409(1):221-7. PMID: 12464262.
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      143. Brown N, Kumar S, Painter CA, Vaughan DE. ACE inhibition versus angiotensin type 1 receptor antagonism: differential effects on PAI-1 over time. Hypertension. 2002 Dec; 40(6):859-65. PMID: 12468570.
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      144. Clark L, Barton JA, Brown N. Assessment of community contamination: a critical approach. Public Health Nurs. 2002 Sep-Oct; 19(5):354-65. PMID: 12182695.
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      145. Brown N, Vaughan DE, Fogo AB. The renin-angiotensin-aldosterone system and fibrinolysis in progressive renal disease. Semin Nephrol. 2002 Sep; 22(5):399-406. PMID: 12224047.
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      146. Meredith S, Feldman P, Frey D, Giammarco L, Hall K, Arnold K, Brown N, Ray WA. Improving medication use in newly admitted home healthcare patients: a randomized controlled trial. J Am Geriatr Soc. 2002 Sep; 50(9):1484-91. PMID: 12383144.
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      147. Geiben-Lynn R, Brown N, Walker BD, Luster AD. Purification of a modified form of bovine antithrombin III as an HIV-1 CD8+ T-cell antiviral factor. J Biol Chem. 2002 Nov 1; 277(44):42352-7. PMID: 12192009.
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      148. Srikumar N, Brown N, Hopkins PN, Jeunemaitre X, Hunt SC, Vaughan DE, Williams GH. PAI-1 in human hypertension: relation to hypertensive groups. Am J Hypertens. 2002 Aug; 15(8):683-90. PMID: 12160190.
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      149. Kaikita K, Schoenhard JA, Painter CA, Ripley RT, Brown N, Fogo AB, Vaughan DE. Potential roles of plasminogen activator system in coronary vascular remodeling induced by long-term nitric oxide synthase inhibition. J Mol Cell Cardiol. 2002 Jun; 34(6):617-27. PMID: 12054849.
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      150. Rosenbaum DA, Pretorius M, Gainer JV, Byrne D, Murphey LJ, Painter CA, Vaughan DE, Brown N. Ethnicity affects vasodilation, but not endothelial tissue plasminogen activator release, in response to bradykinin. Arterioscler Thromb Vasc Biol. 2002 Jun 1; 22(6):1023-8. PMID: 12067915.
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      151. Brown N, Vaughan DE, Fogo AB. Aldosterone and PAI-1: implications for renal injury. J Nephrol. 2002 May-Jun; 15(3):230-5. PMID: 12113592.
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      152. Felder RA, Sanada H, Xu J, Yu PY, Wang Z, Watanabe H, Asico LD, Wang W, Zheng S, Yamaguchi I, Williams SM, Gainer J, Brown N, Hazen-Martin D, Wong LJ, Robillard JE, Carey RM, Eisner GM, Jose PA. G protein-coupled receptor kinase 4 gene variants in human essential hypertension. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3872-7. PMID: 11904438.
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      153. Pretorius M, Rosenbaum DA, Lefebvre J, Vaughan DE, Brown N. Smoking impairs bradykinin-stimulated t-PA release. Hypertension. 2002 Mar 1; 39(3):767-71. PMID: 11897760.
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      154. Lefebvre J, Murphey LJ, Hartert TV, Jiao Shan R, Simmons WH, Brown N. Dipeptidyl peptidase IV activity in patients with ACE-inhibitor-associated angioedema. Hypertension. 2002 Feb; 39(2 Pt 2):460-4. PMID: 11882590.
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      155. Sawathiparnich P, Kumar S, Vaughan DE, Brown N. Spironolactone abolishes the relationship between aldosterone and plasminogen activator inhibitor-1 in humans. J Clin Endocrinol Metab. 2002 Feb; 87(2):448-52. PMID: 11836266.
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      156. Brown N, Abbas A, Byrne D, Schoenhard JA, Vaughan DE. Comparative effects of estrogen and angiotensin-converting enzyme inhibition on plasminogen activator inhibitor-1 in healthy postmenopausal women. Circulation. 2002 Jan 22; 105(3):304-9. PMID: 11804984.
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      157. Gainer JV, Stein CM, Neal T, Vaughan DE, Brown N. Interactive Effect of Ethnicity and ACE Insertion/Deletion Polymorphism on Vascular Reactivity. Hypertension. 2001 Jan; 37(1):46-51. PMID: 11208755.
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