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    Elliott, John

    TitleEnvir Sustainability Manager
    SchoolLawrence Berkeley National Lab
    DepartmentLaboratory Directorate
    Address1 Cyclotron Road
    Berkeley CA 94720
    Phone510/486-7188
    vCardDownload vCard

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Xu H, Lu H, Xu Z, Luan L, Li C, Xu Y, Dong K, Zhang J, Li X, Li Y, Liu G, Gong S, Zhao YG, Liu A, Zhang Y, Zhang W, Cai X, Xiang JN, Elliott J, Lin X. Discovery of CNS Penetrant CXCR2 Antagonists for the Potential Treatment of CNS Demyelinating Disorders. ACS Med Chem Lett. 2016 Apr 14; 7(4):397-402. PMID: 27096048.
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      2. Wang Y, Yang T, Liu Q, Ma Y, Yang L, Zhou L, Xiang Z, Cheng Z, Lu S, Orband-Miller LA, Zhang W, Wu Q, Zhang K, Li Y, Xiang JN, Elliott J, Leung S, Ren F, Lin X. Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent ROR?t inverse agonists. Bioorg Med Chem. 2015 Sep 1; 23(17):5293-302. PMID: 26277758.
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      3. Wang Y, Cai W, Cheng Y, Yang T, Liu Q, Zhang G, Meng Q, Han F, Huang Y, Zhou L, Xiang Z, Zhao YG, Xu Y, Cheng Z, Lu S, Wu Q, Xiang JN, Elliott J, Leung S, Ren F, Lin X. Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant ROR?t Inhibitors. ACS Med Chem Lett. 2015 Jul 9; 6(7):787-92. PMID: 26191367.
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      4. Lu H, Yang T, Xu Z, Wren PB, Zhang Y, Cai X, Patel M, Dong K, Zhang Q, Zhang W, Guan X, Xiang J, Elliott J, Lin X, Ren F. 2-Aminopyrimidin-4(1H)-one as the novel bioisostere of urea: Discovery of novel and potent CXCR2 antagonists. Bioorg Med Chem Lett. 2014 Dec 1; 24(23):5493-6. PMID: 25455491.
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      5. Wang Y, Cai W, Zhang G, Yang T, Liu Q, Cheng Y, Zhou L, Ma Y, Cheng Z, Lu S, Zhao YG, Zhang W, Xiang Z, Wang S, Yang L, Wu Q, Orband-Miller LA, Xu Y, Zhang J, Gao R, Huxdorf M, Xiang JN, Zhong Z, Elliott J, Leung S, Lin X. Discovery of novel N-(5-(arylcarbonyl)thiazol-2-yl)amides and N-(5-(arylcarbonyl)thiophen-2-yl)amides as potent ROR?t inhibitors. Bioorg Med Chem. 2014 Jan 15; 22(2):692-702. PMID: 24388993.
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      6. Yang T, Liu Q, Cheng Y, Cai W, Ma Y, Yang L, Wu Q, Orband-Miller LA, Zhou L, Xiang Z, Huxdorf M, Zhang W, Zhang J, Xiang JN, Leung S, Qiu Y, Zhong Z, Elliott J, Lin X, Wang Y. Discovery of Tertiary Amine and Indole Derivatives as Potent ROR?t Inverse Agonists. ACS Med Chem Lett. 2014 Jan 9; 5(1):65-8. PMID: 24900774.
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      7. Deng G, Zhao B, Ma Y, Xu Q, Wang H, Yang L, Zhang Q, Guo TB, Zhang W, Jiao Y, Cai X, Zhang J, Liu H, Guan X, Lu H, Xiang J, Elliott J, Lin X, Ren F. Novel complex crystal structure of prolyl hydroxylase domain-containing protein 2 (PHD2): 2,8-Diazaspiro[4.5]decan-1-ones as potent, orally bioavailable PHD2 inhibitors. Bioorg Med Chem. 2013 Nov 1; 21(21):6349-58. PMID: 24055079.
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      8. Deng G, Meng Q, Liu Q, Xu X, Xu Q, Ren F, Guo TB, Lu H, Xiang JN, Elliott J, Lin X. Identification of benzoxazole analogs as novel, S1P(3) sparing S1P(1) agonists. Bioorg Med Chem Lett. 2012 Jun 15; 22(12):3973-7. PMID: 22583616.
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      9. Ren F, Deng G, Wang H, Luan L, Meng Q, Xu Q, Xu H, Xu X, Zhang H, Zhao B, Li C, Guo TB, Yang J, Zhang W, Zhao Y, Jia Q, Lu H, Xiang JN, Elliott J, Lin X. Discovery of novel 1,2,4-thiadiazole derivatives as potent, orally active agonists of sphingosine 1-phosphate receptor subtype 1 (S1P(1)). J Med Chem. 2012 May 10; 55(9):4286-96. PMID: 22500954.
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      10. Meng Q, Zhao B, Xu Q, Xu X, Deng G, Li C, Luan L, Ren F, Wang H, Xu H, Xu Y, Zhang H, Xiang JN, Elliott J, Guo TB, Zhao Y, Zhang W, Lu H, Lin X. Indole-propionic acid derivatives as potent, S1P3-sparing and EAE efficacious sphingosine-1-phosphate 1 (S1P1) receptor agonists. Bioorg Med Chem Lett. 2012 Apr 15; 22(8):2794-7. PMID: 22429468.
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      11. Xu H, Zhang H, Luan L, Xu Y, Li C, Wang Y, Han F, Yang T, Ren F, Xiang JN, Elliott J, Zhao Y, Guo TB, Lu H, Zhang W, Hirst D, Lindon M, Lin X. Discovery of thiadiazole amides as potent, S1P3-sparing agonists of sphingosine-1-phosphate 1 (S1P1) receptor. Bioorg Med Chem Lett. 2012 Apr 1; 22(7):2456-9. PMID: 22386243.
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      12. Wan Z, Hall A, Sang Y, Xiang JN, Yang E, Smith B, Harrison DC, Yang G, Yu H, Price HS, Wang J, Hawkins J, Lau LF, Johnson MR, Li T, Zhao W, Mitchell WL, Su X, Zhang X, Zhou Y, Jin Y, Tong Z, Cheng Z, Hussain I, Elliott J, Matsuoka Y. Pyridine-derived ?-secretase modulators. Bioorg Med Chem Lett. 2011 Aug 15; 21(16):4832-5. PMID: 21742495.
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      13. Wan Z, Hall A, Jin Y, Xiang JN, Yang E, Eatherton A, Smith B, Yang G, Yu H, Wang J, Ye L, Lau LF, Yang T, Mitchell W, Cai W, Zhang X, Sang Y, Wang Y, Tong Z, Cheng Z, Hussain I, Elliott J, Matsuoka Y. Pyridazine-derived ?-secretase modulators. Bioorg Med Chem Lett. 2011 Jul 1; 21(13):4016-9. PMID: 21636276.
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      14. Qian X, McDonald A, Zhou HJ, Adams ND, Parrish CA, Duffy KJ, Fitch DM, Tedesco R, Ashcraft LW, Yao B, Jiang H, Huang JK, Marin MV, Aroyan CE, Wang J, Ahmed S, Burgess JL, Chaudhari AM, Donatelli CA, Darcy MG, Ridgers LH, Newlander KA, Schmidt SJ, Chai D, Colón M, Zimmerman MN, Lad L, Sakowicz R, Schauer S, Belmont L, Baliga R, Pierce DW, Finer JT, Wang Z, Morgan BP, Morgans DJ, Auger KR, Sung CM, Carson JD, Luo L, Hugger ED, Copeland RA, Sutton D, Elliott J, Jackson JR, Wood KW, Dhanak D, Bergnes G, Knight SD. Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295. ACS Med Chem Lett. 2010 Apr 8; 1(1):30-4. PMID: 24900171.
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      15. Nie H, Widdowson KL, Palovich MR, Fu W, Elliott J, Bryan DL, Burman M, Schmidt DB, Foley JJ, Sarau HM, Busch-Petersen J. N,N'-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptors. Bioorg Med Chem Lett. 2006 Nov 1; 16(21):5513-6. PMID: 16934456.
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      16. Ohlstein EH, Johnson AG, Elliott J, Romanic AM. New strategies in drug discovery. Methods Mol Biol. 2006; 316:1-11. PMID: 16671397.
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      17. Jin Q, Nie H, McCleland BW, Widdowson KL, Palovich MR, Elliott J, Goodman RM, Burman M, Sarau HM, Ward KW, Nord M, Orr BM, Gorycki PD, Busch-Petersen J. Discovery of potent and orally bioavailable N,N'-diarylurea antagonists for the CXCR2 chemokine receptor. Bioorg Med Chem Lett. 2004 Sep 6; 14(17):4375-8. PMID: 15357956.
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      18. Widdowson KL, Elliott J, Veber DF, Nie H, Rutledge MC, McCleland BW, Xiang JN, Jurewicz AJ, Hertzberg RP, Foley JJ, Griswold DE, Martin L, Lee JM, White JR, Sarau HM. Evaluation of potent and selective small-molecule antagonists for the CXCR2 chemokine receptor. J Med Chem. 2004 Mar 11; 47(6):1319-21. PMID: 14998320.
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      19. Ohlstein EH, Ruffolo RR, Elliott J. Drug discovery in the next millennium. Annu Rev Pharmacol Toxicol. 2000; 40:177-91. PMID: 10836132.
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      20. Raval P, Bingham S, Aiyar N, Elliott J, Hunter AJ, Ohlstein EH, Parsons AA. Trigeminal nerve ganglion stimulation-induced neurovascular reflexes in the anaesthetized cat: role of endothelin(B) receptors in carotid vasodilatation. Br J Pharmacol. 1999 Jan; 126(2):485-93. PMID: 10077242.
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      21. Underwood DC, Bochnowicz S, Osborn RR, Luttmann MA, Louden CS, Hart TK, Elliott J, Hay DW. Effect of SB 217242 on hypoxia-induced cardiopulmonary changes in the high altitude-sensitive rat. Pulm Pharmacol Ther. 1999; 12(1):13-26. PMID: 10208832.
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      22. Ohlstein EH, Nambi P, Hay DW, Gellai M, Brooks DP, Luengo J, Xiang JN, Elliott J. Nonpeptide endothelin receptor antagonists. XI. Pharmacological characterization of SB 234551, a high-affinity and selective nonpeptide ETA receptor antagonist. J Pharmacol Exp Ther. 1998 Aug; 286(2):650-6. PMID: 9694916.
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      23. Xiang JN, Nambi P, Ohlstein EH, Elliott J. An efficient approach to the synthesis of 1,3-diaryl-1,2,3,4-[4H]-tetrahydronaphthalene-2-carboxylic acids. Bioorg Med Chem. 1998 Jun; 6(6):695-700. PMID: 9681135.
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      24. Douglas SA, Nichols AJ, Feuerstein GZ, Elliott J, Ohlstein EH. SB 209670 inhibits the arrhythmogenic actions of endothelin-1 in the anesthetized dog. J Cardiovasc Pharmacol. 1998; 31 Suppl 1:S99-102. PMID: 9595411.
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      25. Willette RN, Sauermelch CF, Storer BL, Guiney S, Luengo JI, Xiang JN, Elliott J, Ohlstein EH. Plasma- and cerebrospinal fluid-immunoreactive endothelin-1: effects of nonpeptide endothelin receptor antagonists with diverse affinity profiles for endothelin-A and endothelin-B receptors. J Cardiovasc Pharmacol. 1998; 31 Suppl 1:S149-57. PMID: 9595425.
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      26. Douglas SA, Nambi P, Gellai M, Luengo JI, Xiang JN, Brooks DP, Ruffolo RR, Elliott J, Ohlstein EH. Pharmacologic characterization of the novel, orally available endothelin-A--selective antagonist SB 247083. J Cardiovasc Pharmacol. 1998; 31 Suppl 1:S273-6. PMID: 9595458.
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      27. Brooks DP, DePalma PD, Pullen M, Elliott J, Ohlstein EH, Nambi P. SB 234551, a novel endothelin--A receptor antagonist, unmasks endothelin-induced renal vasodilatation in the dog. J Cardiovasc Pharmacol. 1998; 31 Suppl 1:S339-41. PMID: 9595475.
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      28. Elliott J, Ohlstein EH, Peishoff CE, Ellens HM, Lago MA. Endothelin receptor antagonists. Pharm Biotechnol. 1998; 11:113-29. PMID: 9760678.
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      29. Ohlstein EH, Elliott J, Feuerstein GZ, Ruffolo RR. Endothelin receptors: receptor classification, novel receptor antagonists, and potential therapeutic targets. Med Res Rev. 1996 Jul; 16(4):365-90. PMID: 8798180.
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      30. Keller PM, Lee CP, Fenwick AE, Atkinson ST, Elliott J, DeWolf WE. Endothelin-converting enzyme: substrate specificity and inhibition by novel analogs of phosphoramidon. Biochem Biophys Res Commun. 1996 Jun 14; 223(2):372-8. PMID: 8670289.
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      31. Warner TD, Elliott J, Ohlstein EH. California dreamin' 'bout endothelin: emerging new therapeutics. Trends Pharmacol Sci. 1996 May; 17(5):177-81. PMID: 8669122.
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      32. Ohlstein EH, Nambi P, Lago A, Hay DW, Beck G, Fong KL, Eddy EP, Smith P, Ellens H, Elliott J. Nonpeptide endothelin receptor antagonists. VI: Pharmacological characterization of SB 217242, a potent and highly bioavailable endothelin receptor antagonist. J Pharmacol Exp Ther. 1996 Feb; 276(2):609-15. PMID: 8632328.
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      33. Gellai M, Jugus M, Fletcher T, Nambi P, Ohlstein EH, Elliott J, Brooks DP. Nonpeptide endothelin receptor antagonists. V: Prevention and reversal of acute renal failure in the rat by SB 209670. J Pharmacol Exp Ther. 1995 Oct; 275(1):200-6. PMID: 7562550.
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      34. Douglas SA, Beck GR, Elliott J, Ohlstein EH. Pharmacological evidence for the presence of three distinct functional endothelin receptor subtypes in the rabbit lateral saphenous vein. Br J Pharmacol. 1995 Apr; 114(8):1529-40. PMID: 7599920.
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      35. Douglas SA, Gellai M, Ezekiel M, Feuerstein GZ, Elliott J, Ohlstein EH. Antihypertensive actions of the novel nonpeptide endothelin receptor antagonist SB 209670. Hypertension. 1995 Apr; 25(4 Pt 2):818-22. PMID: 7721437.
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      36. Douglas SA, Edwards RM, Elliott J, Ohlstein EH. In vivo pharmacological characterization of the non-peptide endothelin receptor antagonist SB 209670. Br J Pharmacol. 1995 Jan; 114(2):405-13. PMID: 7881741.
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      37. Douglas SA, Beck GR, Elliott J, Ohlstein EH. Pharmacologic evidence for the presence of three functional endothelin receptor subtypes in rabbit saphenous vein. J Cardiovasc Pharmacol. 1995; 26 Suppl 3:S163-8. PMID: 8587352.
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      38. Douglas SA, Vickery-Clark LM, Louden C, Elliott J, Ohlstein EH. Endothelin receptor subtypes in the pathogenesis of angioplasty-induced neointima formation in the rat: a comparison of selective ETA receptor antagonism and dual ETA/ETB receptor antagonism using BQ-123 and SB 209670. J Cardiovasc Pharmacol. 1995; 26 Suppl 3:S186-9. PMID: 8587358.
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      39. Beck GR, Douglas SA, Elliott J, Ohlstein EH. Agonist-dependent inhibition by peptide and nonpeptide endothelin receptor antagonists in the rabbit isolated pulmonary artery. J Cardiovasc Pharmacol. 1995; 26 Suppl 3:S385-8. PMID: 8587422.
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      40. Barone FC, White RF, Elliott J, Feuerstein GZ, Ohlstein EH. The endothelin receptor antagonist SB 217242 reduces cerebral focal ischemic brain injury. J Cardiovasc Pharmacol. 1995; 26 Suppl 3:S404-7. PMID: 8587428.
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      41. Nambi P, Elshourbagy N, Wu HL, Pullen M, Ohlstein EH, Brooks DP, Lago MA, Elliott J, Gleason JG, Ruffolo RR. Nonpeptide endothelin receptor antagonists. I. Effects on binding and signal transduction on human endothelinA and endothelinB receptors. J Pharmacol Exp Ther. 1994 Nov; 271(2):755-61. PMID: 7965793.
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      42. Ohlstein EH, Beck GR, Douglas SA, Nambi P, Lago MA, Gleason JG, Ruffolo RR, Feuerstein G, Elliott J. Nonpeptide endothelin receptor antagonists. II. Pharmacological characterization of SB 209670. J Pharmacol Exp Ther. 1994 Nov; 271(2):762-8. PMID: 7965794.
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      43. Brooks DP, dePalma PD, Gellai M, Nambi P, Ohlstein EH, Elliott J, Gleason JG, Ruffolo RR. Nonpeptide endothelin receptor antagonists. III. Effect of SB 209670 and BQ123 on acute renal failure in anesthetized dogs. J Pharmacol Exp Ther. 1994 Nov; 271(2):769-75. PMID: 7965795.
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      44. Lee JA, Elliott J, Sutiphong JA, Friesen WJ, Ohlstein EH, Stadel JM, Gleason JG, Peishoff CE. Tyr-129 is important to the peptide ligand affinity and selectivity of human endothelin type A receptor. Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15):7164-8. PMID: 8041764.
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      45. Douglas SA, Louden C, Vickery-Clark LM, Storer BL, Hart T, Feuerstein GZ, Elliott J, Ohlstein EH. A role for endogenous endothelin-1 in neointimal formation after rat carotid artery balloon angioplasty. Protective effects of the novel nonpeptide endothelin receptor antagonist SB 209670. Circ Res. 1994 Jul; 75(1):190-7. PMID: 8013078.
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      46. Elliott J, Lago MA, Cousins RD, Gao A, Leber JD, Erhard KF, Nambi P, Elshourbagy NA, Kumar C, Lee JA. 1,3-Diarylindan-2-carboxylic acids, potent and selective non-peptide endothelin receptor antagonists. J Med Chem. 1994 May 27; 37(11):1553-7. PMID: 8201588.
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      47. Ali FE, Bennett DB, Calvo RR, Elliott J, Hwang SM, Ku TW, Lago MA, Nichols AJ, Romoff TT, Shah DH. Conformationally constrained peptides and semipeptides derived from RGD as potent inhibitors of the platelet fibrinogen receptor and platelet aggregation. J Med Chem. 1994 Mar 18; 37(6):769-80. PMID: 8145226.
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      48. Douglas SA, Elliott J, Ohlstein EH. Regional vasodilation to endothelin-1 is mediated by a non-ETA receptor subtype in the anaesthetized rat: effect of BQ-123 on systemic haemodynamic responses. Eur J Pharmacol. 1992 Oct 20; 221(2-3):315-24. PMID: 1426008.
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      49. Ohlstein EH, Arleth A, Bryan H, Elliott J, Sung CP. The selective endothelin ETA receptor antagonist BQ123 antagonizes endothelin-1-mediated mitogenesis. Eur J Pharmacol. 1992 Apr 10; 225(4):347-50. PMID: 1323478.
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      50. Mayer RJ, Louis-Flamberg P, Elliott J, Fisher M, Leber J. Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A synthase by antibiotic 1233A and other beta-lactones. Biochem Biophys Res Commun. 1990 Jun 15; 169(2):610-6. PMID: 1972621.
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      51. Louis-Flamberg P, Peishoff CE, Bryan DL, Leber J, Elliott J, Metcalf BW, Mayer RJ. Slow binding inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Biochemistry. 1990 May 1; 29(17):4115-20. PMID: 2361135.
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