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    Bielicki, John

    TitleBiochemist Scientist/Engineer
    SchoolLawrence Berkeley National Lab
    DepartmentMolecular Biophys & Integ Bio
    Address1 Cyclotron Road
    Berkeley CA 94720
    Phone510/495-2208
    vCardDownload vCard

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Lek MT, Cruz S, Ibe NU, Beck WHJ, Bielicki J, Weers PMM, Narayanaswami V. Swapping the N- and C-terminal domains of human apolipoprotein E3 and AI reveals insights into their structure/activity relationship. PLoS One. 2017; 12(6):e0178346. PMID: 28644829.
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      2. Boehm-Cagan A, Bar R, Harats D, Shaish A, Levkovitz H, Bielicki J, Johansson JO, Michaelson DM. Differential Effects of apoE4 and Activation of ABCA1 on Brain and Plasma Lipoproteins. PLoS One. 2016; 11(11):e0166195. PMID: 27824936.
        View in: PubMed
      3. Boehm-Cagan A, Bar R, Liraz O, Bielicki J, Johansson JO, Michaelson DM. ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies. J Alzheimers Dis. 2016 Oct 4; 54(3):1219-1233. PMID: 27567858.
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      4. Bielicki J. ABCA1 agonist peptides for the treatment of disease. Curr Opin Lipidol. 2016 Feb; 27(1):40-6. PMID: 26655293.
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      5. Hafiane A, Bielicki J, Johansson JO, Genest J. Novel Apo E-Derived ABCA1 Agonist Peptide (CS-6253) Promotes Reverse Cholesterol Transport and Induces Formation of preß-1 HDL In Vitro. PLoS One. 2015; 10(7):e0131997. PMID: 26207756.
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      6. Hafiane A, Bielicki J, Johansson JO, Genest J. Apolipoprotein E derived HDL mimetic peptide ATI-5261 promotes nascent HDL formation and reverse cholesterol transport in vitro. Biochim Biophys Acta. 2014 Oct; 1842(10):1498-512. PMID: 25091998.
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      7. Kim SH, Kothari S, Patel AB, Bielicki J, Narayanaswami V. A pyrene based fluorescence approach to study conformation of apolipoprotein E3 in macrophage-generated nascent high density lipoprotein. Biochem Biophys Res Commun. 2014 Jul 18; 450(1):124-8. PMID: 24866239.
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      8. Tran TN, Kosaraju MG, Tamamizu-Kato S, Akintunde O, Zheng Y, Bielicki J, Pinkerton K, Uchida K, Lee YY, Narayanaswami V. Acrolein modification impairs key functional features of rat apolipoprotein e: identification of modified sites by mass spectrometry. Biochemistry. 2014 Jan 21; 53(2):361-75. PMID: 24325674.
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      9. Zheng Y, Patel AB, Narayanaswami V, Bielicki J. Retention of a-helical structure by HDL mimetic peptide ATI-5261 upon extensive dilution represents an important determinant for stimulating ABCA1 cholesterol efflux with high efficiency. Biochem Biophys Res Commun. 2013 Nov 8; 441(1):71-6. PMID: 24129191.
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      10. Zheng Y, Kim SH, Patel AB, Narayanaswami V, Iavarone AT, Hura GL, Bielicki J. The positional specificity of EXXK motifs within an amphipathic a-helix dictates preferential lysine modification by acrolein: implications for the design of high-density lipoprotein mimetic peptides. Biochemistry. 2012 Aug 14; 51(32):6400-12. PMID: 22800301.
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      11. Zheng Y, Patel AB, Narayanaswami V, Hura GL, Hang B, Bielicki J. HDL mimetic peptide ATI-5261 forms an oligomeric assembly in solution that dissociates to monomers upon dilution. Biochemistry. 2011 May 17; 50(19):4068-76. PMID: 21476522.
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      12. Bielicki J, Zhang H, Cortez Y, Zheng Y, Narayanaswami V, Patel A, Johansson J, Azhar S. A new HDL mimetic peptide that stimulates cellular cholesterol efflux with high efficiency greatly reduces atherosclerosis in mice. J Lipid Res. 2010 Jun; 51(6):1496-503. PMID: 20075422.
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      13. Vedhachalam C, Narayanaswami V, Neto N, Forte TM, Phillips MC, Lund-Katz S, Bielicki J. The C-terminal lipid-binding domain of apolipoprotein E is a highly efficient mediator of ABCA1-dependent cholesterol efflux that promotes the assembly of high-density lipoproteins. Biochemistry. 2007 Mar 13; 46(10):2583-93. PMID: 17305370.
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      14. Beckstead JA, Block BL, Bielicki J, Kay CM, Oda MN, Ryan RO. Combined N- and C-terminal truncation of human apolipoprotein A-I yields a folded, functional central domain. Biochemistry. 2005 Mar 22; 44(11):4591-9. PMID: 15766290.
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      15. Verreth W, De Keyzer D, Pelat M, Verhamme P, Ganame J, Bielicki J, Mertens A, Quarck R, Benhabilès N, Marguerie G, Mackness B, Mackness M, Ninio E, Herregods MC, Balligand JL, Holvoet P. Weight-loss-associated induction of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant mice. Circulation. 2004 Nov 16; 110(20):3259-69. PMID: 15533870.
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      16. Natarajan P, Forte TM, Chu B, Phillips MC, Oram JF, Bielicki J. Identification of an apolipoprotein A-I structural element that mediates cellular cholesterol efflux and stabilizes ATP binding cassette transporter A1. J Biol Chem. 2004 Jun 4; 279(23):24044-52. PMID: 15051721.
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      17. Beckstead JA, Oda MN, Martin DD, Forte TM, Bielicki J, Berger T, Luty R, Kay CM, Ryan RO. Structure-function studies of human apolipoprotein A-V: a regulator of plasma lipid homeostasis. Biochemistry. 2003 Aug 12; 42(31):9416-23. PMID: 12899628.
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      18. Mertens A, Verhamme P, Bielicki J, Phillips MC, Quarck R, Verreth W, Stengel D, Ninio E, Navab M, Mackness B, Mackness M, Holvoet P. Increased low-density lipoprotein oxidation and impaired high-density lipoprotein antioxidant defense are associated with increased macrophage homing and atherosclerosis in dyslipidemic obese mice: LCAT gene transfer decreases atherosclerosis. Circulation. 2003 Apr 1; 107(12):1640-6. PMID: 12668499.
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      19. Jia Z, Natarajan P, Forte TM, Bielicki J. Thiol-bearing synthetic peptides retain the antioxidant activity of apolipoproteinA-I(Milano). Biochem Biophys Res Commun. 2002 Sep 20; 297(2):206-13. PMID: 12237103.
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      20. Forte TM, Subbanagounder G, Berliner JA, Blanche PJ, Clermont AO, Jia Z, Oda MN, Krauss RM, Bielicki J. Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice. J Lipid Res. 2002 Mar; 43(3):477-85. PMID: 11893784.
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      21. Bielicki J, Oda MN. Apolipoprotein A-I(Milano) and apolipoprotein A-I(Paris) exhibit an antioxidant activity distinct from that of wild-type apolipoprotein A-I. Biochemistry. 2002 Feb 12; 41(6):2089-96. PMID: 11827556.
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      22. Oda MN, Bielicki J, Ho TT, Berger T, Rubin EM, Forte TM. Paraoxonase 1 overexpression in mice and its effect on high-density lipoproteins. Biochem Biophys Res Commun. 2002 Jan 25; 290(3):921-7. PMID: 11798161.
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      23. Brushia RJ, Forte TM, Oda MN, La Du BN, Bielicki J. Baculovirus-mediated expression and purification of human serum paraoxonase 1A. J Lipid Res. 2001 Jun; 42(6):951-8. PMID: 11369803.
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      24. Cavelier LB, Qiu Y, Bielicki J, Afzal V, Cheng JF, Rubin EM. Regulation and activity of the human ABCA1 gene in transgenic mice. J Biol Chem. 2001 May 25; 276(21):18046-51. PMID: 11279093.
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      25. Bielicki J, Knoff LJ, Tribble DL, Forte TM. Relative sensitivities of plasma lecithin:cholesterol acyltransferase, platelet-activating factor acetylhydrolase, and paraoxonase to in vitro gas-phase cigarette smoke exposure. Atherosclerosis. 2001 Mar; 155(1):71-8. PMID: 11223428.
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      26. Oda MN, Bielicki J, Berger T, Forte TM. Cysteine substitutions in apolipoprotein A-I primary structure modulate paraoxonase activity. Biochemistry. 2001 Feb 13; 40(6):1710-8. PMID: 11327831.
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      27. Bielicki J, Forte TM. Evidence that lipid hydroperoxides inhibit plasma lecithin:cholesterol acyltransferase activity. J Lipid Res. 1999 May; 40(5):948-54. PMID: 10224164.
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      28. Bielicki J, McCall MR, Forte TM. Apolipoprotein A-I promotes cholesterol release and apolipoprotein E recruitment from THP-1 macrophage-like foam cells. J Lipid Res. 1999 Jan; 40(1):85-92. PMID: 9869653.
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      29. Lindholm EM, Bielicki J, Curtiss LK, Rubin EM, Forte TM. Deletion of amino acids Glu146-->Arg160 in human apolipoprotein A-I (ApoA-ISeattle) alters lecithin:cholesterol acyltransferase activity and recruitment of cell phospholipid. Biochemistry. 1998 Apr 7; 37(14):4863-8. PMID: 9538003.
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      30. Chiesa G, Stoltzfus LJ, Michelagnoli S, Bielicki J, Santi M, Forte TM, Sirtori CR, Franceschini G, Rubin EM. Elevated triglycerides and low HDL cholesterol in transgenic mice expressing human apolipoprotein A-I(Milano). Atherosclerosis. 1998 Jan; 136(1):139-46. PMID: 9544740.
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      31. Bielicki J, Hopwood JJ, Melville EL, Anson DS. Recombinant human sulphamidase: expression, amplification, purification and characterization. Biochem J. 1998 Jan 1; 329 ( Pt 1):145-50. PMID: 9405287.
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      32. Bielicki J, Forte TM, McCall MR, Stoltzfus LJ, Chiesa G, Sirtori CR, Franceschini G, Rubin EM. High density lipoprotein particle size restriction in apolipoprotein A-I(Milano) transgenic mice. J Lipid Res. 1997 Nov; 38(11):2314-21. PMID: 9392429.
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      33. Litjens T, Bielicki J, Anson DS, Friderici K, Jones MZ, Hopwood JJ. Expression, purification and characterization of recombinant caprine N-acetylglucosamine-6-sulphatase. Biochem J. 1997 Oct 1; 327 ( Pt 1):89-94. PMID: 9355739.
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      34. Bielicki J, McCall MR, Stoltzfus LJ, Ravandi A, Kuksis A, Rubin EM, Forte TM. Evidence that apolipoprotein A-IMilano has reduced capacity, compared with wild-type apolipoprotein A-I, to recruit membrane cholesterol. Arterioscler Thromb Vasc Biol. 1997 Sep; 17(9):1637-43. PMID: 9327756.
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      35. Yogalingam G, Litjens T, Bielicki J, Crawley AC, Muller V, Anson DS, Hopwood JJ. Feline mucopolysaccharidosis type VI. Characterization of recombinant N-acetylgalactosamine 4-sulfatase and identification of a mutation causing the disease. J Biol Chem. 1996 Nov 1; 271(44):27259-65. PMID: 8910299.
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      36. Bielicki J, Forte TM, McCall MR. Minimally oxidized LDL is a potent inhibitor of lecithin:cholesterol acyltransferase activity. J Lipid Res. 1996 May; 37(5):1012-21. PMID: 8725153.
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      37. Forte TM, Bielicki J, Knoff L, McCall MR. Structural relationships between nascent apoA-I-containing particles that are extracellularly assembled in cell culture. J Lipid Res. 1996 May; 37(5):1076-85. PMID: 8725159.
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      38. Crawley AC, Brooks DA, Muller VJ, Petersen BA, Isaac EL, Bielicki J, King BM, Boulter CD, Moore AJ, Fazzalari NL, Anson DS, Byers S, Hopwood JJ. Enzyme replacement therapy in a feline model of Maroteaux-Lamy syndrome. J Clin Invest. 1996 Apr 15; 97(8):1864-73. PMID: 8621770.
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      39. Bielicki J, Fuller M, Guo XH, Morris CP, Hopewood JJ, Anson DS. Expression, purification and characterization of recombinant human N-acetylgalactosamine-6-sulphatase. Biochem J. 1995 Oct 1; 311 ( Pt 1):333-9. PMID: 7575473.
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      40. McCall MR, Tang JY, Bielicki J, Forte TM. Inhibition of lecithin-cholesterol acyltransferase and modification of HDL apolipoproteins by aldehydes. Arterioscler Thromb Vasc Biol. 1995 Oct; 15(10):1599-606. PMID: 7583533.
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      41. Bielicki J, Forte TM, McCall MR. Gas-phase cigarette smoke inhibits plasma lecithin-cholesterol acyltransferase activity by modification of the enzyme's free thiols. Biochim Biophys Acta. 1995 Aug 24; 1258(1):35-40. PMID: 7654778.
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      42. Yancey PG, Bielicki J, Johnson WJ, Lund-Katz S, Palgunachari MN, Anantharamaiah GM, Segrest JP, Phillips MC, Rothblat GH. Efflux of cellular cholesterol and phospholipid to lipid-free apolipoproteins and class A amphipathic peptides. Biochemistry. 1995 Jun 20; 34(24):7955-65. PMID: 7794908.
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      43. Bielicki J, McCall MR, van den Berg JJ, Kuypers FA, Forte TM. Copper and gas-phase cigarette smoke inhibit plasma lecithin:cholesterol acyltransferase activity by different mechanisms. J Lipid Res. 1995 Feb; 36(2):322-31. PMID: 7751820.
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      44. Forte TM, Bielicki J, Goth-Goldstein R, Selmek J, McCall MR. Recruitment of cell phospholipids and cholesterol by apolipoproteins A-II and A-I: formation of nascent apolipoprotein-specific HDL that differ in size, phospholipid composition, and reactivity with LCAT. J Lipid Res. 1995 Jan; 36(1):148-57. PMID: 7706940.
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      45. Bielicki J, Hopwood JJ, Wilson PJ, Anson DS. Recombinant human iduronate-2-sulphatase: correction of mucopolysaccharidosis-type II fibroblasts and characterization of the purified enzyme. Biochem J. 1993 Jan 1; 289 ( Pt 1):241-6. PMID: 8424762.
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      46. Bielicki J, Johnson WJ, Weinberg RB, Glick JM, Rothblat GH. Efflux of lipid from fibroblasts to apolipoproteins: dependence on elevated levels of cellular unesterified cholesterol. J Lipid Res. 1992 Nov; 33(11):1699-709. PMID: 1464753.
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      47. Anson DS, Taylor JA, Bielicki J, Harper GS, Peters C, Gibson GJ, Hopwood JJ. Correction of human mucopolysaccharidosis type-VI fibroblasts with recombinant N-acetylgalactosamine-4-sulphatase. Biochem J. 1992 Jun 15; 284 ( Pt 3):789-94. PMID: 1320379.
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      48. Bielicki J, Johnson WJ, Glick JM, Rothblat GH. Efflux of phospholipid from fibroblasts with normal and elevated levels of cholesterol. Biochim Biophys Acta. 1991 Aug 20; 1085(1):7-14. PMID: 1892880.
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      49. Bielicki J, Freeman C, Clements PR, Hopwood JJ. Human liver iduronate-2-sulphatase. Purification, characterization and catalytic properties. Biochem J. 1990 Oct 1; 271(1):75-86. PMID: 2222422.
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