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    Wyrobek, Andrew

    TitleGeneticist Senior Sci/Engr
    SchoolLawrence Berkeley National Lab
    DepartmentBiological Systems & Eng
    Address1 Cyclotron Road
    Berkeley CA 94720
    Phone510/486-7375
    vCardDownload vCard

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Wyrobek A, Britten RA. Individual variations in dose response for spatial memory learning among outbred wistar rats exposed from 5 to 20 cGy of (56) Fe particles. Environ Mol Mutagen. 2016 Jun; 57(5):331-40. PMID: 27237589.
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      2. Britten RA, Jewell JS, Miller VD, Davis LK, Hadley MM, Wyrobek A. Impaired Spatial Memory Performance in Adult Wistar Rats Exposed to Low (5-20 cGy) Doses of 1 GeV/n (56)Fe Particles. Radiat Res. 2016 Mar; 185(3):332-7. PMID: 26943453.
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      3. Marchetti F, Bishop J, Gingerich J, Wyrobek A. Meiotic interstrand DNA damage escapes paternal repair and causes chromosomal aberrations in the zygote by maternal misrepair. Sci Rep. 2015; 5:7689. PMID: 25567288.
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      4. Snijders AM, Langley S, Mao JH, Bhatnagar S, Bjornstad KA, Rosen CJ, Lo A, Huang Y, Blakely EA, Karpen GH, Bissell MJ, Wyrobek A. An interferon signature identified by RNA-sequencing of mammary tissues varies across the estrous cycle and is predictive of metastasis-free survival. Oncotarget. 2014 Jun 30; 5(12):4011-25. PMID: 24994117.
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      5. Kim D, Marchetti F, Chen Z, Zaric S, Wilson RJ, Hall DA, Gaster RS, Lee JR, Wang J, Osterfeld SJ, Yu H, White RM, Blakely WF, Peterson LE, Bhatnagar S, Mannion B, Tseng S, Roth K, Coleman M, Snijders AM, Wyrobek A, Wang SX. Nanosensor dosimetry of mouse blood proteins after exposure to ionizing radiation. Sci Rep. 2013; 3:2234. PMID: 23868657.
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      6. Budworth H, Snijders AM, Marchetti F, Mannion B, Bhatnagar S, Kwoh E, Tan Y, Wang SX, Blakely WF, Coleman M, Peterson L, Wyrobek A. DNA repair and cell cycle biomarkers of radiation exposure and inflammation stress in human blood. PLoS One. 2012; 7(11):e48619. PMID: 23144912.
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      7. Snijders AM, Marchetti F, Bhatnagar S, Duru N, Han J, Hu Z, Mao JH, Gray JW, Wyrobek A. Genetic differences in transcript responses to low-dose ionizing radiation identify tissue functions associated with breast cancer susceptibility. PLoS One. 2012; 7(10):e45394. PMID: 23077491.
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      8. Schmid TE, Grant PG, Marchetti F, Weldon RH, Eskenazi B, Wyrobek A. Elemental composition of human semen is associated with motility and genomic sperm defects among older men. Hum Reprod. 2013 Jan; 28(1):274-82. PMID: 23042799.
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      9. Schmid TE, Eskenazi B, Marchetti F, Young S, Weldon RH, Baumgartner A, Anderson D, Wyrobek A. Micronutrients intake is associated with improved sperm DNA quality in older men. Fertil Steril. 2012 Nov; 98(5):1130-7.e1. PMID: 22935557.
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      10. Marchetti F, Eskenazi B, Weldon RH, Li G, Zhang L, Rappaport SM, Schmid TE, Xing C, Kurtovich E, Wyrobek A. Occupational exposure to benzene and chromosomal structural aberrations in the sperm of Chinese men. Environ Health Perspect. 2012 Feb; 120(2):229-34. PMID: 22086566.
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      11. Wyrobek A, Manohar CF, Krishnan VV, Nelson DO, Furtado MR, Bhattacharya MS, Marchetti F, Coleman MA. Low dose radiation response curves, networks and pathways in human lymphoblastoid cells exposed from 1 to 10cGy of acute gamma radiation. Mutat Res. 2011 Jun 17; 722(2):119-30. PMID: 21497671.
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      12. Lapuk A, Marr H, Jakkula L, Pedro H, Bhattacharya S, Purdom E, Hu Z, Simpson K, Pachter L, Durinck S, Wang N, Parvin B, Fontenay G, Speed T, Garbe J, Stampfer M, Bayandorian H, Dorton S, Clark TA, Schweitzer A, Wyrobek A, Feiler H, Spellman P, Conboy J, Gray JW. Exon-level microarray analyses identify alternative splicing programs in breast cancer. Mol Cancer Res. 2010 Jul; 8(7):961-74. PMID: 20605923.
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      13. Xing C, Marchetti F, Li G, Weldon RH, Kurtovich E, Young S, Schmid TE, Zhang L, Rappaport S, Waidyanatha S, Wyrobek A, Eskenazi B. Benzene exposure near the U.S. permissible limit is associated with sperm aneuploidy. Environ Health Perspect. 2010 Jun; 118(6):833-9. PMID: 20418200.
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      14. Kuo WL, Das D, Ziyad S, Bhattacharya S, Gibb WJ, Heiser LM, Sadanandam A, Fontenay GV, Hu Z, Wang NJ, Bayani N, Feiler HS, Neve RM, Wyrobek A, Spellman PT, Marton LJ, Gray JW. A systems analysis of the chemosensitivity of breast cancer cells to the polyamine analogue PG-11047. BMC Med. 2009; 7:77. PMID: 20003408.
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      15. Garbe JC, Bhattacharya S, Merchant B, Bassett E, Swisshelm K, Feiler HS, Wyrobek A, Stampfer MR. Molecular distinctions between stasis and telomere attrition senescence barriers shown by long-term culture of normal human mammary epithelial cells. Cancer Res. 2009 Oct 1; 69(19):7557-68. PMID: 19773443.
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      16. Mirzoeva OK, Das D, Heiser LM, Bhattacharya S, Siwak D, Gendelman R, Bayani N, Wang NJ, Neve RM, Guan Y, Hu Z, Knight Z, Feiler HS, Gascard P, Parvin B, Spellman PT, Shokat KM, Wyrobek A, Bissell MJ, McCormick F, Kuo WL, Mills GB, Gray JW, Korn WM. Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res. 2009 Jan 15; 69(2):565-72. PMID: 19147570.
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      17. Lowe XR, Bhattacharya S, Marchetti F, Wyrobek A. Early brain response to low-dose radiation exposure involves molecular networks and pathways associated with cognitive functions, advanced aging and Alzheimer's disease. Radiat Res. 2009 Jan; 171(1):53-65. PMID: 19138050.
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      18. Lowe XR, Marchetti F, Lu X, Wyrobek A. Molecular stress response in the CNS of mice after systemic exposure to interferon-alpha, ionizing radiation and ketamine. Neurotoxicology. 2009 Mar; 30(2):261-8. PMID: 19162068.
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      19. Marchetti F, Bishop J, Lowe X, Wyrobek A. Chromosomal mosaicism in mouse two-cell embryos after paternal exposure to acrylamide. Toxicol Sci. 2009 Jan; 107(1):194-205. PMID: 18930949.
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      20. Straume T, Amundson SA, Blakely WF, Burns FJ, Chen A, Dainiak N, Franklin S, Leary JA, Loftus DJ, Morgan WF, Pellmar TC, Stolc V, Turteltaub KW, Vaughan AT, Vijayakumar S, Wyrobek A. NASA Radiation Biomarker Workshop, September 27-28, 2007. Radiat Res. 2008 Sep; 170(3):393-405. PMID: 18763867.
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      21. Young SS, Eskenazi B, Marchetti FM, Block G, Wyrobek A. The association of folate, zinc and antioxidant intake with sperm aneuploidy in healthy non-smoking men. Hum Reprod. 2008 May; 23(5):1014-22. PMID: 18353905.
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      22. Marchetti F, Wyrobek A. DNA repair decline during mouse spermiogenesis results in the accumulation of heritable DNA damage. DNA Repair (Amst). 2008 Apr 2; 7(4):572-81. PMID: 18282746.
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      23. Marchetti F, Cabreros D, Wyrobek A. Laboratory methods for the detection of chromosomal structural aberrations in human and mouse sperm by fluorescence in situ hybridization. Methods Mol Biol. 2008; 410:241-71. PMID: 18642604.
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      24. Marchetti F, Essers J, Kanaar R, Wyrobek A. Disruption of maternal DNA repair increases sperm-derived chromosomal aberrations. Proc Natl Acad Sci U S A. 2007 Nov 6; 104(45):17725-9. PMID: 17978187.
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      25. Lowe XR, Lu X, Marchetti F, Wyrobek A. The expression of Troponin T1 gene is induced by ketamine in adult mouse brain. Brain Res. 2007 Oct 12; 1174:7-17. PMID: 17850769.
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      26. Sloter ED, Marchetti F, Eskenazi B, Weldon RH, Nath J, Cabreros D, Wyrobek A. Frequency of human sperm carrying structural aberrations of chromosome 1 increases with advancing age. Fertil Steril. 2007 May; 87(5):1077-86. PMID: 17433321.
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      27. Wyrobek A, Mulvihill JJ, Wassom JS, Malling HV, Shelby MD, Lewis SE, Witt KL, Preston RJ, Perreault SD, Allen JW, Demarini DM, Woychik RP, Bishop JB. Assessing human germ-cell mutagenesis in the Postgenome Era: a celebration of the legacy of William Lawson (Bill) Russell. Environ Mol Mutagen. 2007 Mar; 48(2):71-95. PMID: 17295306.
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      28. Schmid TE, Eskenazi B, Baumgartner A, Marchetti F, Young S, Weldon R, Anderson D, Wyrobek A. The effects of male age on sperm DNA damage in healthy non-smokers. Hum Reprod. 2007 Jan; 22(1):180-7. PMID: 17053003.
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      29. Marchetti F, Coleman MA, Jones IM, Wyrobek A. Candidate protein biodosimeters of human exposure to ionizing radiation. Int J Radiat Biol. 2006 Sep; 82(9):605-39. PMID: 17050475.
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      30. Tomascik-Cheeseman LM, Lowe XR, Eskenazi B, Kidd S, Nath J, Moore D, Wyrobek A. A father of four consecutive trisomic pregnancies with elevated frequencies of associated aneuploid sperm. Am J Med Genet A. 2006 Sep 1; 140A(17):1840-5. PMID: 16892324.
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      31. Sloter E, Schmid TE, Marchetti F, Eskenazi B, Nath J, Wyrobek A. Quantitative effects of male age on sperm motion. Hum Reprod. 2006 Nov; 21(11):2868-75. PMID: 16793993.
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      32. Wyrobek A, Eskenazi B, Young S, Arnheim N, Tiemann-Boege I, Jabs EW, Glaser RL, Pearson FS, Evenson D. Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm. Proc Natl Acad Sci U S A. 2006 Jun 20; 103(25):9601-6. PMID: 16766665.
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      33. Marchetti F, Pearson FS, Bishop JB, Wyrobek A. Etoposide induces chromosomal abnormalities in mouse spermatocytes and stem cell spermatogonia. Hum Reprod. 2006 Apr; 21(4):888-95. PMID: 16311288.
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      34. Coleman MA, Yin E, Peterson LE, Nelson D, Sorensen K, Tucker JD, Wyrobek A. Low-dose irradiation alters the transcript profiles of human lymphoblastoid cells including genes associated with cytogenetic radioadaptive response. Radiat Res. 2005 Oct; 164(4 Pt 1):369-82. PMID: 16187739.
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      35. Silver EW, Eskenazi B, Evenson DP, Block G, Young S, Wyrobek A. Effect of antioxidant intake on sperm chromatin stability in healthy nonsmoking men. J Androl. 2005 Jul-Aug; 26(4):550-6. PMID: 15955895.
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      36. Marchetti F, Wyrobek A. Mechanisms and consequences of paternally-transmitted chromosomal abnormalities. Birth Defects Res C Embryo Today. 2005 Jun; 75(2):112-29. PMID: 16035041.
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      37. Wyrobek A, Schmid TE, Marchetti F. Cross-species sperm-FISH assays for chemical testing and assessing paternal risk for chromosomally abnormal pregnancies. Environ Mol Mutagen. 2005 Mar-Apr; 45(2-3):271-83. PMID: 15754381.
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      38. Eskenazi B, Kidd SA, Marks AR, Sloter E, Block G, Wyrobek A. Antioxidant intake is associated with semen quality in healthy men. Hum Reprod. 2005 Apr; 20(4):1006-12. PMID: 15665024.
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      39. Wyrobek A, Schmid TE, Marchetti F. Relative susceptibilities of male germ cells to genetic defects induced by cancer chemotherapies. J Natl Cancer Inst Monogr. 2005; (34):31-5. PMID: 15784819.
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      40. Zudova D, Wyrobek A, Bishop J, Marchetti F. Impaired fertility in T-stock female mice after superovulation. Reproduction. 2004 Nov; 128(5):573-81. PMID: 15509703.
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      41. Motin VL, Georgescu AM, Fitch JP, Gu PP, Nelson DO, Mabery SL, Garnham JB, Sokhansanj BA, Ott LL, Coleman MA, Elliott JM, Kegelmeyer LM, Wyrobek A, Slezak TR, Brubaker RR, Garcia E. Temporal global changes in gene expression during temperature transition in Yersinia pestis. J Bacteriol. 2004 Sep; 186(18):6298-305. PMID: 15342600.
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      42. Tomascik-Cheeseman LM, Coleman MA, Marchetti F, Nelson DO, Kegelmeyer LM, Nath J, Wyrobek A. Differential basal expression of genes associated with stress response, damage control, and DNA repair among mouse tissues. Mutat Res. 2004 Jul 11; 561(1-2):1-14. PMID: 15238225.
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      43. Schmid TE, Brinkworth MH, Hill F, Sloter E, Kamischke A, Marchetti F, Nieschlag E, Wyrobek A. Detection of structural and numerical chromosomal abnormalities by ACM-FISH analysis in sperm of oligozoospermic infertility patients. Hum Reprod. 2004 Jun; 19(6):1395-400. PMID: 15117895.
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      44. Sloter E, Nath J, Eskenazi B, Wyrobek A. Effects of male age on the frequencies of germinal and heritable chromosomal abnormalities in humans and rodents. Fertil Steril. 2004 Apr; 81(4):925-43. PMID: 15066442.
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      45. Marchetti F, Bishop JB, Cosentino L, Moore D, Wyrobek A. Paternally transmitted chromosomal aberrations in mouse zygotes determine their embryonic fate. Biol Reprod. 2004 Mar; 70(3):616-24. PMID: 14585809.
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      46. Hill FS, Marchetti F, Liechty M, Bishop J, Hozier J, Wyrobek A. A new FISH assay to simultaneously detect structural and numerical chromosomal abnormalities in mouse sperm. Mol Reprod Dev. 2003 Oct; 66(2):172-80. PMID: 12950105.
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      47. Yin E, Nelson DO, Coleman MA, Peterson LE, Wyrobek A. Gene expression changes in mouse brain after exposure to low-dose ionizing radiation. Int J Radiat Biol. 2003 Oct; 79(10):759-75. PMID: 14630535.
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      48. Glaser RL, Broman KW, Schulman RL, Eskenazi B, Wyrobek A, Jabs EW. The paternal-age effect in Apert syndrome is due, in part, to the increased frequency of mutations in sperm. Am J Hum Genet. 2003 Oct; 73(4):939-47. PMID: 12900791.
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      49. Barton TS, Wyrobek A, Hill FS, Robaire B, Hales BF. Numerical chromosomal abnormalities in rat epididymal spermatozoa following chronic cyclophosphamide exposure. Biol Reprod. 2003 Oct; 69(4):1150-7. PMID: 12773405.
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      50. Eskenazi B, Wyrobek A, Sloter E, Kidd SA, Moore L, Young S, Moore D. The association of age and semen quality in healthy men. Hum Reprod. 2003 Feb; 18(2):447-54. PMID: 12571189.
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      51. Perreault SD, Aitken RJ, Baker HW, Evenson DP, Huszar G, Irvine DS, Morris ID, Morris RA, Robbins WA, Sakkas D, Spano M, Wyrobek A. Integrating new tests of sperm genetic integrity into semen analysis: breakout group discussion. Adv Exp Med Biol. 2003; 518:253-68. PMID: 12817694.
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      52. Frias S, Van Hummelen P, Meistrich ML, Lowe XR, Hagemeister FB, Shelby MD, Bishop JB, Wyrobek A. NOVP chemotherapy for Hodgkin's disease transiently induces sperm aneuploidies associated with the major clinical aneuploidy syndromes involving chromosomes X, Y, 18, and 21. Cancer Res. 2003 Jan 1; 63(1):44-51. PMID: 12517776.
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      53. Marchetti F, Wyrobek A. PAINT/DAPI analysis of mouse zygotes to detect paternally transmitted chromosomal aberrations. Adv Exp Med Biol. 2003; 518:131-45. PMID: 12817682.
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      54. Tiemann-Boege I, Navidi W, Grewal R, Cohn D, Eskenazi B, Wyrobek A, Arnheim N. The observed human sperm mutation frequency cannot explain the achondroplasia paternal age effect. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):14952-7. PMID: 12397172.
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      55. Sorensen KJ, Attix CM, Christian AT, Wyrobek A, Tucker JD. Adaptive response induction and variation in human lymphoblastoid cell lines. Mutat Res. 2002 Aug 26; 519(1-2):15-24. PMID: 12160888.
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      56. Rubes J, Vozdova M, Robbins WA, Rezacova O, Perreault SD, Wyrobek A. Stable variants of sperm aneuploidy among healthy men show associations between germinal and somatic aneuploidy. Am J Hum Genet. 2002 Jun; 70(6):1507-19. PMID: 11992257.
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      57. Eskenazi B, Wyrobek A, Kidd SA, Lowe X, Moore D, Weisiger K, Aylstock M. Sperm aneuploidy in fathers of children with paternally and maternally inherited Klinefelter syndrome. Hum Reprod. 2002 Mar; 17(3):576-83. PMID: 11870106.
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      58. Tomascik-Cheeseman L, Marchetti F, Lowe X, Shamanski FL, Nath J, Pedersen RA, Wyrobek A. CENP-B is not critical for meiotic chromosome segregation in male mice. Mutat Res. 2002 Jan 15; 513(1-2):197-203. PMID: 11719105.
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      59. Lowe X, Eskenazi B, Nelson DO, Kidd S, Alme A, Wyrobek A. Frequency of XY sperm increases with age in fathers of boys with Klinefelter syndrome. Am J Hum Genet. 2001 Nov; 69(5):1046-54. PMID: 11582569.
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      60. Schmid TE, Lowe X, Marchetti F, Bishop J, Haseman J, Wyrobek A. Evaluation of inter-scorer and inter-laboratory reliability of the mouse epididymal sperm aneuploidy (m-ESA) assay. Mutagenesis. 2001 May; 16(3):189-95. PMID: 11320142.
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      61. Marchetti F, Bishop JB, Lowe X, Generoso WM, Hozier J, Wyrobek A. Etoposide induces heritable chromosomal aberrations and aneuploidy during male meiosis in the mouse. Proc Natl Acad Sci U S A. 2001 Mar 27; 98(7):3952-7. PMID: 11274416.
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      62. Kidd SA, Eskenazi B, Wyrobek A. Effects of male age on semen quality and fertility: a review of the literature. Fertil Steril. 2001 Feb; 75(2):237-48. PMID: 11172821.
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      63. Sloter ED, Lowe X, Moore II DH, Nath J, Wyrobek A. Multicolor FISH analysis of chromosomal breaks, duplications, deletions, and numerical abnormalities in the sperm of healthy men. Am J Hum Genet. 2000 Oct; 67(4):862-72. PMID: 10961911.
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      64. Marchetti F, Lowe X, Bishop J, Wyrobek A. Absence of selection against aneuploid mouse sperm at fertilization. Biol Reprod. 1999 Oct; 61(4):948-54. PMID: 10491629.
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      65. Holland N, Ahlborn T, Turteltaub K, Markee C, Moore D, Wyrobek A, Smith MT. Acrylamide causes preimplantation abnormalities in embryos and induces chromatin-adducts in male germ cells of mice. Reprod Toxicol. 1999 May-Jun; 13(3):167-78. PMID: 10378466.
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      66. Baumgartner A, Van Hummelen P, Lowe XR, Adler ID, Wyrobek A. Numerical and structural chromosomal abnormalities detected in human sperm with a combination of multicolor FISH assays. Environ Mol Mutagen. 1999; 33(1):49-58. PMID: 10037323.
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      67. Rubes J, Lowe X, Moore D, Perreault S, Slott V, Evenson D, Selevan SG, Wyrobek A. Smoking cigarettes is associated with increased sperm disomy in teenage men. Fertil Steril. 1998 Oct; 70(4):715-23. PMID: 9797104.
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      68. Mascio LN, Yuen BK, Kegelmeyer WP, Matsumoto K, Briner J, Wyrobek A. Advances in the automated detection of metaphase chromosomes labeled with fluorescence dyes. Cytometry. 1998 Sep 1; 33(1):10-8. PMID: 9725554.
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      69. Lowe XR, de Stoppelaar JM, Bishop J, Cassel M, Hoebee B, Moore D, Wyrobek A. Epididymal sperm aneuploidies in three strains of rats detected by multicolor fluorescence in situ hybridization. Environ Mol Mutagen. 1998; 31(2):125-32. PMID: 9544190.
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      70. Titenko-Holland N, Ahlborn T, Lowe X, Shang N, Smith MT, Wyrobek A. Micronuclei and developmental abnormalities in 4-day mouse embryos after paternal treatment with acrylamide. Environ Mol Mutagen. 1998; 31(3):206-17. PMID: 9585259.
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      71. Van Hummelen P, Manchester D, Lowe X, Wyrobek A. Meiotic segregation, recombination, and gamete aneuploidy assessed in a t(1;10)(p22.1;q22.3) reciprocal translocation carrier by three- and four-probe multicolor FISH in sperm. Am J Hum Genet. 1997 Sep; 61(3):651-9. PMID: 9326331.
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      72. Robbins WA, Meistrich ML, Moore D, Hagemeister FB, Weier HU, Cassel MJ, Wilson G, Eskenazi B, Wyrobek A. Chemotherapy induces transient sex chromosomal and autosomal aneuploidy in human sperm. Nat Genet. 1997 May; 16(1):74-8. PMID: 9140398.
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      73. Vine MF, Setzer RW, Everson RB, Wyrobek A. Human sperm morphometry and smoking, caffeine, and alcohol consumption. Reprod Toxicol. 1997 Mar-Jun; 11(2-3):179-84. PMID: 9100290.
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      74. Wyrobek A, Schrader SM, Perreault SD, Fenster L, Huszar G, Katz DF, Osorio AM, Sublet V, Evenson D. Assessment of reproductive disorders and birth defects in communities near hazardous chemical sites. III. Guidelines for field studies of male reproductive disorders. Reprod Toxicol. 1997 Mar-Jun; 11(2-3):243-59. PMID: 9100299.
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      75. Fenster L, Katz DF, Wyrobek A, Pieper C, Rempel DM, Oman D, Swan SH. Effects of psychological stress on human semen quality. J Androl. 1997 Mar-Apr; 18(2):194-202. PMID: 9154514.
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      76. Marchetti F, Lowe X, Bishop J, Wyrobek A. Induction of chromosomal aberrations in mouse zygotes by acrylamide treatment of male germ cells and their correlation with dominant lethality and heritable translocations. Environ Mol Mutagen. 1997; 30(4):410-7. PMID: 9435882.
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      77. Baulch JE, Lowe XR, Bishop JB, Wyrobek A. Evidence for a parent-of-origin effect on sperm aneuploidy in mice carrying Robertsonian translocations as analyzed by fluorescence in situ hybridization. Mutat Res. 1996 Dec; 372(2):269-78. PMID: 9015145.
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      78. Adler ID, Bishop J, Lowe X, Schmid TE, Schriever-Schwemmer G, Xu W, Wyrobek A. Spontaneous rates of sex chromosomal aneuploidies in sperm and offspring of mice: a validation of the detection of aneuploid sperm by fluorescence in situ hybridization. Mutat Res. 1996 Dec; 372(2):259-68. PMID: 9015144.
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      79. Marchetti F, Lowe X, Moore DH, Bishop J, Wyrobek A. Paternally inherited chromosomal structural aberrations detected in mouse first-cleavage zygote metaphases by multicolour fluorescence in situ hybridization painting. Chromosome Res. 1996 Dec; 4(8):604-13. PMID: 9024977.
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      80. Van Hummelen P, Lowe XR, Wyrobek A. Simultaneous detection of structural and numerical chromosome abnormalities in sperm of healthy men by multicolor fluorescence in situ hybridization. Hum Genet. 1996 Nov; 98(5):608-15. PMID: 8882884.
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      81. Lowe X, O'Hogan S, Moore D, Bishop J, Wyrobek A. Aneuploid epididymal sperm detected in chromosomally normal and Robertsonian translocation-bearing mice using a new three-chromosome FISH method. Chromosoma. 1996 Oct; 105(4):204-10. PMID: 8854879.
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      82. Wyrobek A, Adler ID. Detection of aneuploidy in human and rodent sperm using FISH and applications of sperm assays of genetic damage in heritable risk evaluation. Mutat Res. 1996 Jun 10; 352(1-2):173-9. PMID: 8676907.
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      83. Fraga CG, Motchnik PA, Wyrobek A, Rempel DM, Ames BN. Smoking and low antioxidant levels increase oxidative damage to sperm DNA. Mutat Res. 1996 Apr 13; 351(2):199-203. PMID: 8622715.
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      84. Musilov√° P, Lee DA, Stratil A, Cepica S, Rubes J, Lowe X, Wyrobek A. Assignment of the porcine IKBA gene (IkappaBalpha) encoding a cytoplasmic inhibitor of the NF-kappaB to chromosome 7q15-q21 by FISH. Mamm Genome. 1996 Apr; 7(4):323-4. PMID: 8661710.
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      85. Nutley EV, Tcheong AC, Allen JW, Collins BW, Ma M, Lowe XR, Bishop JB, Moore DH, Wyrobek A. Micronuclei induced in round spermatids of mice after stem-cell treatment with chloral hydrate: evaluations with centromeric DNA probes and kinetochore antibodies. Environ Mol Mutagen. 1996; 28(2):80-9. PMID: 8844988.
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      86. Bishop JB, Dellarco VL, Hassold T, Ferguson LR, Wyrobek A, Friedman JM. Aneuploidy in germ cells: etiologies and risk factors. Environ Mol Mutagen. 1996; 28(3):159-66. PMID: 8908176.
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      87. Wyrobek A, Aardema M, Eichenlaub-Ritter U, Ferguson L, Marchetti F. Mechanisms and targets involved in maternal and paternal age effects on numerical aneuploidy. Environ Mol Mutagen. 1996; 28(3):254-64. PMID: 8908184.
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      88. Lowe X, Collins B, Allen J, Titenko-Holland N, Breneman J, van Beek M, Bishop J, Wyrobek A. Aneuploidies and micronuclei in the germ cells of male mice of advanced age. Mutat Res. 1995 Oct; 338(1-6):59-76. PMID: 7565883.
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      89. Wyrobek A, Lowe X, Pinkel D, Bishop J. Aneuploidy in late-step spermatids of mice detected by two-chromosome fluorescence in situ hybridization. Mol Reprod Dev. 1995 Feb; 40(2):259-66. PMID: 7766420.
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      90. Robbins WA, Baulch JE, Moore D, Weier HU, Blakey D, Wyrobek A. Three-probe fluorescence in situ hybridization to assess chromosome X, Y, and 8 aneuploidy in sperm of 14 men from two healthy groups: evidence for a paternal age effect on sperm aneuploidy. Reprod Fertil Dev. 1995; 7(4):799-809. PMID: 8711214.
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      91. MacGregor JT, Tucker JD, Eastmond DA, Wyrobek A. Integration of cytogenetic assays with toxicology studies. Environ Mol Mutagen. 1995; 25(4):328-37. PMID: 7607189.
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      92. Wyrobek A, Robbins WA, Mehraein Y, Pinkel D, Weier HU. Detection of sex chromosomal aneuploidies X-X, Y-Y, and X-Y in human sperm using two-chromosome fluorescence in situ hybridization. Am J Med Genet. 1994 Oct 15; 53(1):1-7. PMID: 7802028.
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      93. Stanker LH, Wyrobek A, McKeown C, Balhorn R. Identification of the binding site of two monoclonal antibodies to human protamine. Mol Immunol. 1993 Dec; 30(18):1633-8. PMID: 7505880.
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      94. Robbins WA, Segraves R, Pinkel D, Wyrobek A. Detection of aneuploid human sperm by fluorescence in situ hybridization: evidence for a donor difference in frequency of sperm disomic for chromosomes 1 and Y. Am J Hum Genet. 1993 Apr; 52(4):799-807. PMID: 8460647.
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      95. Wyrobek A. Methods and concepts in detecting abnormal reproductive outcomes of paternal origin. Reprod Toxicol. 1993; 7 Suppl 1:3-16. PMID: 8400638.
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      96. Stanker LH, McKeown C, Balhorn R, Lee C, Mazrimas J, Goralka M, Wyrobek A. Immunological evidence for a P2 protamine precursor in mature rat sperm. Mol Reprod Dev. 1992 Dec; 33(4):481-8. PMID: 1472378.
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      97. Eskenazi B, Wyrobek A, Fenster L, Katz DF, Sadler M, Lee J, Hudes M, Rempel DM. A study of the effect of perchloroethylene exposure on semen quality in dry cleaning workers. Am J Ind Med. 1991; 20(5):575-91. PMID: 1793101.
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      98. Eskenazi B, Fenster L, Hudes M, Wyrobek A, Katz DF, Gerson J, Rempel DM. A study of the effect of perchloroethylene exposure on the reproductive outcomes of wives of dry-cleaning workers. Am J Ind Med. 1991; 20(5):593-600. PMID: 1793102.
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      99. Wyrobek A, Alhborn T, Balhorn R, Stanker L, Pinkel D. Fluorescence in situ hybridization to Y chromosomes in decondensed human sperm nuclei. Mol Reprod Dev. 1990 Nov; 27(3):200-8. PMID: 2078335.
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      100. Tucker JD, Wyrobek A, Ashworth LK, Christensen ML, Burton GV, Carrano AV, Everson RB. Induction, accumulation, and persistence of sister chromatid exchanges in women with breast cancer receiving cyclophosphamide, adriamycin, and 5-fluorouracil chemotherapy. Cancer Res. 1990 Aug 15; 50(16):4951-6. PMID: 2379160.
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      101. Bigbee WL, Wyrobek A, Langlois RG, Jensen RH, Everson RB. The effect of chemotherapy on the in vivo frequency of glycophorin A 'null' variant erythrocytes. Mutat Res. 1990 Mar; 240(3):165-75. PMID: 2314410.
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      102. Moruzzi JF, Wyrobek A, Mayall BH, Gledhill BL. Quantification and classification of human sperm morphology by computer-assisted image analysis. Fertil Steril. 1988 Jul; 50(1):142-52. PMID: 3384107.
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      103. Wyrobek A. Application of human sperm parameters for monitoring. Prog Clin Biol Res. 1986; 207:101-20. PMID: 3960868.
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      104. Meistrich ML, Goldstein LS, Wyrobek A. Long-term infertility and dominant lethal mutations in male mice treated with adriamycin. Mutat Res. 1985 Oct; 152(1):53-65. PMID: 4047085.
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      105. Rosenberg MJ, Wyrobek A, Ratcliffe J, Gordon LA, Watchmaker G, Fox SH, Moore DH, Hornung RW. Sperm as an indicator of reproductive risk among petroleum refinery workers. Br J Ind Med. 1985 Feb; 42(2):123-7. PMID: 3970871.
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      106. Brandriff B, Gordon L, Ashworth L, Watchmaker G, Moore D, Wyrobek A, Carrano AV. Chromosomes of human sperm: variability among normal individuals. Hum Genet. 1985; 70(1):18-24. PMID: 3838965.
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      107. Halamka J, Gray JW, Gledhill BL, Lake S, Wyrobek A. Estimation of the frequency of malformed sperm by slit scan flow cytometry. Cytometry. 1984 Jul; 5(4):333-8. PMID: 6468173.
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      108. Balhorn R, Weston S, Thomas C, Wyrobek A. DNA packaging in mouse spermatids. Synthesis of protamine variants and four transition proteins. Exp Cell Res. 1984 Feb; 150(2):298-308. PMID: 6692853.
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      109. Wyrobek A. Identifying agents that damage human spermatogenesis: abnormalities in sperm concentration and morphology. IARC Sci Publ. 1984; (59):387-402. PMID: 6545290.
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      110. Wyrobek A, Watchmaker G, Gordon L. An evaluation of sperm tests as indicators of germ-cell damage in men exposed to chemical or physical agents. Teratog Carcinog Mutagen. 1984; 4(1):83-107. PMID: 6143423.
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      111. Brandriff B, Gordon L, Ashworth L, Watchmaker G, Carrano A, Wyrobek A. Chromosomal abnormalities in human sperm: comparisons among four healthy men. Hum Genet. 1984; 66(2-3):193-201. PMID: 6714980.
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      112. Wyrobek A, Watchmaker G, Gordon L. An evaluation of sperm tests as indicators of germ-cell damage in men exposed to chemical or physical agents. Prog Clin Biol Res. 1984; 160:385-405. PMID: 6382335.
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      113. Da Cunha MF, Meistrich ML, Ried HL, Gordon LA, Watchmaker G, Wyrobek A. Active sperm production after cancer chemotherapy with doxorubicin. J Urol. 1983 Nov; 130(5):927-30. PMID: 6415299.
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      114. Pinkel D, Gledhill BL, Van Dilla MA, Lake S, Wyrobek A. Radiation-induced DNA content variability in mouse sperm. Radiat Res. 1983 Sep; 95(3):550-65. PMID: 6193556.
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      115. Wyrobek A, Gordon LA, Burkhart JG, Francis MW, Kapp RW, Letz G, Malling HV, Topham JC, Whorton MD. An evaluation of human sperm as indicators of chemically induced alterations of spermatogenic function. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat Res. 1983 May; 115(1):73-148. PMID: 6835247.
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      116. Wyrobek A, Gordon LA, Burkhart JG, Francis MW, Kapp RW, Letz G, Malling HV, Topham JC, Whorton MD. An evaluation of the mouse sperm morphology test and other sperm tests in nonhuman mammals. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat Res. 1983 May; 115(1):1-72. PMID: 6835246.
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      117. Wyrobek A. Methods for evaluating the effects of environmental chemicals on human sperm production. Environ Health Perspect. 1983 Feb; 48:53-9. PMID: 6825635.
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      118. Moore DH, Bennett DE, Kranzler D, Wyrobek A. Quantitative methods of measuring the sensitivity of the mouse sperm morphology assay. Anal Quant Cytol. 1982 Sep; 4(3):199-206. PMID: 7149485.
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      119. da Cunha MF, Meistrich ML, Haq MM, Gordon LA, Wyrobek A. Temporary effects of AMSA (4'-(9-acridinylamino) methanesulfon-m-anisidide) chemotherapy on spermatogenesis. Cancer. 1982 Jun 15; 49(12):2459-62. PMID: 7074561.
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      120. Benaron DA, Gray JW, Gledhill BL, Lake S, Wyrobek A, Young IT. Quantification of mammalian sperm morphology by slit-scan flow cytometry. Cytometry. 1982 Mar; 2(5):344-9. PMID: 7075397.
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      121. Wyrobek A, Brodsky J, Gordon L, Moore DH, Watchmaker G, Cohen EN. Sperm studies in anesthesiologists. Anesthesiology. 1981 Nov; 55(5):527-32. PMID: 7294406.
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      122. Wyrobek A, Watchmaker G, Gordon L, Wong K, Moore D, Whorton D. Sperm shape abnormalities in carbaryl-exposed employees. Environ Health Perspect. 1981 Aug; 40:255-65. PMID: 6791917.
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      123. Wyrobek A. Changes in mammalian sperm morphology after X-ray and chemical exposures. Genetics. 1979 May; 92(1 Pt 1 Suppl):s105-19. PMID: 385431.
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      124. Balhorn R, Gledhill BL, Wyrobek A. Mouse sperm chromatin proteins: quantitative isolation and partial characterization. Biochemistry. 1977 Sep 6; 16(18):4074-80. PMID: 911755.
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      125. Wyrobek A, Meistrich ML, Furrer R, Bruce WR. Physical characteristics of mouse sperm nuclei. Biophys J. 1976 Jul; 16(7):811-25. PMID: 938720.
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      126. Wyrobek A, Heddle JA, Bruce WR. Chromosomal abnormalities and the morphology of mouse sperm heads. Can J Genet Cytol. 1975 Dec; 17(4):675-81. PMID: 1203773.
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      127. Wyrobek A, Bruce WR. Chemical induction of sperm abnormalities in mice. Proc Natl Acad Sci U S A. 1975 Nov; 72(11):4425-9. PMID: 1060122.
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      128. Bruce WR, Furrer R, Wyrobek A. Abnormalities in the shape of murine sperm after acute testicular x-irradiation. Mutat Res. 1974 Jun; 23(3):381-6. PMID: 4407800.
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      129. Loir M, Wyrobek A. Density separation of mouse spermatid nuclei. Exp Cell Res. 1972 Nov; 75(1):261-5. PMID: 4635884.
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